P
Pauline Schaap
Researcher at University of Dundee
Publications - 148
Citations - 5266
Pauline Schaap is an academic researcher from University of Dundee. The author has contributed to research in topics: Dictyostelium discoideum & Dictyostelium. The author has an hindex of 41, co-authored 141 publications receiving 4851 citations. Previous affiliations of Pauline Schaap include University of Groningen & Leiden University.
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Journal ArticleDOI
Loss of the Polyketide Synthase StlB Results in Stalk Cell Overproduction in Polysphondylium violaceum
Takaaki B. Narita,Takaaki B. Narita,Yoshinori Kawabe,Koryu Kin,Richard A. Gibbs,Adam Kuspa,Adam Kuspa,Donna M. Muzny,Stephen Richards,Stephen Richards,Joan E. Strassmann,Richard Sucgang,Kim C. Worley,Pauline Schaap +13 more
TL;DR: Sequenced and annotated the Polysphondylium violaceum genome, performed cell type-specific transcriptomics to identify cell-type marker genes, and developed transformation and gene knock-out procedures for Pvio indicate that, although conserved, stlB and its product acquired both a novel role in the group 4 Dictyostelia and a role opposite to that in its sister group.
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Two ras genes in Dictyostelium minutum show high sequence homology, but different developmental regulation from Dictyostelium discoideum rasD and rasG genes.
TL;DR: The social amoeba Dictyostelium discoideum expresses five ras genes at different stages of development, one of them, DdrasD, is expressed during postaggregative development and transcription is induced by extracellular cAMP as discussed by the authors.
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Universal signals control slime mold stalk formation
TL;DR: The data indicate that the extracellular signals controlling stalk formation and their intracellular signaling cascades including gene regulatory proteins remained highly conserved during slime mold evolution.
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Glycogen synthase kinase 3 promotes multicellular development over unicellular encystation in encysting Dictyostelia
TL;DR: The data show that GSK3 has a deeply conserved role in controlling cytokinesis, but not spore differentiation in Dictyostelia, and that gsk3− amoebas entered into encystation under conditions that in wild type favour aggregation and fruiting body formation.
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Transformation with vectors harboring the NEOR selection marker induces germination-specific adenylylcyclase activity in Dictyostelium cells
TL;DR: It is concluded that the amino-glycoside phosphotransferase encoded by the very commonly used NEOR selection marker induces ectopic ACG activity in Dictyostelium cells.