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Pauline Schaap
Researcher at University of Dundee
Publications - 148
Citations - 5266
Pauline Schaap is an academic researcher from University of Dundee. The author has contributed to research in topics: Dictyostelium discoideum & Dictyostelium. The author has an hindex of 41, co-authored 141 publications receiving 4851 citations. Previous affiliations of Pauline Schaap include University of Groningen & Leiden University.
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Cell cycle phase in Dictyostelium discoideum is correlated with the expression of cyclic AMP production, detection, and degradation. Involvement of cyclic AMP signaling in cell sorting.
TL;DR: This work investigated the expression of the cAMP chemotactic system during development of synchronized E and L cells and found that E cells exhibit cAMP-binding activity, cell surfacecAMP-phosphodiesterase (mPDE) activity, and the ability to relay cAMP signals at least 2 hr earlier and to higher levels than L cells.
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Dual role of cAMP during Dictyostelium development.
TL;DR: Mutants as well as strains obtained by reverse genetics will be reviewed which lead to the current understanding of the role of intracellular cAMP in the differentiation of both stalk and spore cells.
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Fingerprinting of adenylyl cyclase activities during Dictyostelium development indicates a dominant role for adenylyl cyclase B in terminal differentiation.
Marcel Meima,Pauline Schaap +1 more
TL;DR: The developmental regulation of ACB and its relationship to REGA suggest that ACB activates PKA and induces terminal differentiation in Dictyostelium, and slugs of null mutants for the intracellular cAMP-phosphodiesterase REGA show ACB activity, which indicates that cAMP accumulation by ACB in living cells is controlled by REGA.
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Analysis of phenotypic evolution in Dictyostelia highlights developmental plasticity as a likely consequence of colonial multicellularity
Maria Romeralo,Anna Skiba,Alejandro Gonzalez-Voyer,Christina Schilde,Hajara M. Lawal,Sylwia Kedziora,Jim C. Cavender,Gernot Glöckner,Gernot Glöckner,Hideko Urushihara,Pauline Schaap +10 more
TL;DR: Overall, dictyostelids show considerable plasticity in the size and shape of multicellular structures, both within and between species, which probably reflects constraints placed by colonial life on developmental control mechanisms.
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Adenylyl cyclase A expression is tip-specific in Dictyostelium slugs and directs StatA nuclear translocation and CudA gene expression.
TL;DR: A gene fusion of the ACA promoter with a labile lacZ derivative is used to study the expression pattern of ACA and suggests that the tip-specific expression of ACA directs tip- Specific nuclear translocation of StatA and tip- specific expression of CudA, which is essential for culmination.