抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Optical wireless communication (OWC) refers to transmission in unguided propagation media through the use of optical carriers, i.e., visible, infrared (IR), and ultraviolet (UV) bands. In this survey, we focus on outdoor terrestrial OWC links which operate in near IR band. These are widely referred to as free space optical (FSO) communication in the literature. FSO systems are used for high rate communication between two fixed points over distances up to several kilometers. In comparison to radio-frequency (RF) counterparts, FSO links have a very high optical bandwidth available, allowing much higher data rates. They are appealing for a wide range of applications such as metropolitan area network (MAN) extension, local area network (LAN)-to-LAN connectivity, fiber back-up, backhaul for wireless cellular networks, disaster recovery, high definition TV and medical image/video transmission, wireless video surveillance/monitoring, and quantum key distribution among others. Despite the major advantages of FSO technology and variety of its application areas, its widespread use has been hampered by its rather disappointing link reliability particularly in long ranges due to atmospheric turbulence-induced fading and sensitivity to weather conditions. In the last five years or so, there has been a surge of interest in FSO research to address these major technical challenges. Several innovative physical layer concepts, originally introduced in the context of RF systems, such as multiple-input multiple-output communication, cooperative diversity, and adaptive transmission have been recently explored for the design of next generation FSO systems. In this paper, we present an up-to-date survey on FSO communication systems. The first part describes FSO channel models and transmitter/receiver structures. In the second part, we provide details on information theoretical limits of FSO channels and algorithmic-level system design research activities to approach these limits. Specific topics include advances in modulation, channel coding, spatial/cooperative diversity techniques, adaptive transmission, and hybrid RF/FSO systems.

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Survey on Free Space Optical Communication: A Communication Theory Perspective

Orbital angular momentum (OAM), which describes the “phase twist” (helical phase pattern) of light beams, has recently gained interest due to its potential applications in many diverse areas. Particularly promising is the use of OAM for optical communications since: (i) coaxially propagating OAM beams with different azimuthal OAM states are mutually orthogonal, (ii) inter-beam crosstalk can be minimized, and (iii) the beams can be efficiently multiplexed and demultiplexed. As a result, multiple OAM states could be used as different carriers for multiplexing and transmitting multiple data streams, thereby potentially increasing the system capacity. In this paper, we review recent progress in OAM beam generation/detection, multiplexing/demultiplexing, and its potential applications in different scenarios including free-space optical communications, fiber-optic communications, and RF communications. Technical challenges and perspectives of OAM beams are also discussed.

Optical communications using orbital angular momentum beams

Underwater wireless information transfer is of great interest to the military, industry, and the scientific community, as it plays an important role in tactical surveillance, pollution monitoring, oil control and maintenance, offshore explorations, climate change monitoring, and oceanography research. In order to facilitate all these activities, there is an increase in the number of unmanned vehicles or devices deployed underwater, which require high bandwidth and high capacity for information transfer underwater. Although tremendous progress has been made in the field of acoustic communication underwater, however, it is limited by bandwidth. All this has led to the proliferation of underwater optical wireless communication (UOWC), as it provides higher data rates than the traditional acoustic communication systems with significantly lower power consumption and simpler computational complexities for short-range wireless links. UOWC has many potential applications ranging from deep oceans to coastal waters. However, the biggest challenge for underwater wireless communication originates from the fundamental characteristics of ocean or sea water; addressing these challenges requires a thorough understanding of complex physio-chemical biological systems. In this paper, the main focus is to understand the feasibility and the reliability of high data rate underwater optical links due to various propagation phenomena that impact the performance of the system. This paper provides an exhaustive overview of recent advances in UOWC. Channel characterization, modulation schemes, coding techniques, and various sources of noise which are specific to UOWC are discussed. This paper not only provides exhaustive research in underwater optical communication but also aims to provide the development of new ideas that would help in the growth of future underwater communication. A hybrid approach to an acousto-optic communication system is presented that complements the existing acoustic system, resulting in high data rates, low latency, and an energy-efficient system.

Underwater Optical Wireless Communication

In this paper, we summarize the fundamental properties and review the latest developments in high power fiber lasers. The review is focused primarily on the most common fiber laser configurations and the associated cladding pumping issues. Special attention is placed on pump combination techniques and the parameters that affect the brightness enhancement observed in single-mode and multimode high power fiber lasers. The review includes the major limitations imposed by fiber nonlinearities and other parasitic effects, such as optical damage, transverse modal instabilities and photodarkening. Finally, the paper summarizes the power evolution in continuous-wave and pulsed ytterbium-doped fiber lasers and their impact on industrial applications.

High Power Fiber Lasers: A Review

Plasma channel generation (or filamentation) using ultraintense laser pulses in dielectric media has a wide spectrum of applications, ranging from remote sensing to terahertz generation to lightning control. So far, laser filamentation has been triggered with the use of ultrafast pulses with axially symmetric spatial beam profiles, thereby generating straight filaments. We report the experimental observation of curved plasma channels generated in air using femtosecond Airy beams. In this unusual propagation regime, the tightly confined main intensity feature of the axially nonsymmetric laser beam propagates along a bent trajectory, leaving a curved plasma channel behind. Secondary channels bifurcate from the primary bent channel at several locations along the beam path. The broadband radiation emanating from different longitudinal sections of the curved filament propagates along angularly resolved trajectories.

https://science.sciencemag.org/content/sci/324/5924/229.full.pdf

Curved Plasma Channel Generation Using Ultraintense Airy Beams

We report a simple optical sensing device capable of measuring the refractive index of liquids propagating in microfluidic channels. The sensor is based on a single-mode optical fiber that is tapered to submicrometer dimensions and immersed in a transparent curable soft polymer. A channel for liquid analyte is created in the immediate vicinity of the taper waist. Light propagating through the tapered section of the fiber extends into the channel, making the optical loss in the system sensitive to the refractive-index difference between the polymer and the liquid. The fabrication process and testing of the prototype sensing devices are described. The sensor can operate both as a highly responsive on–off device and in the continuous measurement mode, with an estimated accuracy of refractive-index measurement of ?5×10?4.

Evanescent field-based optical fiber sensing device for measuring the refractive index of liquids in microfluidic channels

We report experiments on the propagation of intense, femtosecond, self-bending Airy laser beams in water. The supercontinuum radiation generated along the curved beam path is angularly resolved in the far field. Spectral maps of this radiation reveal the changing character of the laser-pulse evolution on propagation.

Filamentation of femtosecond laser Airy beams in water.

In an earlier publication we demonstrated that by using pairs of pulses of different colors (e.g., red and blue) it is possible to excite a dilute ensemble of molecules such that lasing and/or gain-swept superradiance is realized in a direction toward the observer. This approach is a conceptual step toward spectroscopic probing at a distance, also known as standoff spectroscopy. In the present paper, we propose a related but simpler approach on the basis of the backward-directed lasing in optically excited dominant constituents of plain air, N2 and O2. This technique relies on the remote generation of a weakly ionized plasma channel through filamentation of an ultraintense femtosecond laser pulse. Subsequent application of an energetic nanosecond pulse or series of pulses boosts the plasma density in the seed channel via avalanche ionization. Depending on the spectral and temporal content of the driving pulses, a transient population inversion is established in either nitrogen- or oxygen-ionized molecules, thus enabling a transient gain for an optical field propagating toward the observer. This technique results in the generation of a strong, coherent, counterpropagating optical probe pulse. Such a probe, combined with a wavelength-tunable laser signal(s) propagating in the forward direction, provides a tool for various remote-sensing applications. The proposed technique can be enhanced by combining it with the gain-swept excitation approach as well as with beam shaping and adaptive optics techniques.

https://www.pnas.org/content/pnas/108/8/3130.full.pdf

Standoff spectroscopy via remote generation of a backward-propagating laser beam

We report experiments and numerical simulations on supercontinuum generation with femtosecond Airy pulses in a highly nonlinear optical fiber. The ability of the Airy waveform to regenerate its dominant intensity peak results in the generation of distinct spectral features. Airy pulses and other self-healing temporal waveforms may be useful for the generation of spectra with desired properties.

Pavel Polynkin

Papers

Curved Plasma Channel Generation Using Ultraintense Airy Beams

Evanescent field-based optical fiber sensing device for measuring the refractive index of liquids in microfluidic channels

Filamentation of femtosecond laser Airy beams in water.

Standoff spectroscopy via remote generation of a backward-propagating laser beam

Supercontinuum generation with femtosecond self-healing Airy pulses.