M
Marieke von Lindern
Researcher at University of Amsterdam
Publications - 89
Citations - 4452
Marieke von Lindern is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Erythropoiesis & Haematopoiesis. The author has an hindex of 36, co-authored 80 publications receiving 4141 citations. Previous affiliations of Marieke von Lindern include Erasmus University Rotterdam & Research Institute of Molecular Pathology.
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Journal ArticleDOI
Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia
A Hermans,Nora Heisterkamp,Marieke von Lindern,Sjozef van Baal,Dies Meijer,Dorien van der Plas,Leanne M. Wiedemann,John Groffen,Dirk Bootsma,Gerard Grosveld +9 more
TL;DR: It is shown that in Ph+bcr- ALL, breakpoints in chromosome 22 occur within the same bcr gene, but more 5' of the bcr, indicating the presence of a novel fusion protein.
Journal ArticleDOI
Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin
Joseph Borg,Petros Papadopoulos,Marianthi Georgitsi,Laura Gutierrez,Godfrey Grech,Godfrey Grech,Pavlos Fanis,Marios Phylactides,Annemieke J.M.H. Verkerk,Peter J. van der Spek,Christian Scerri,Christian Scerri,Wilhelmina Cassar,Wilhelmina Cassar,Ruth Galdies,Ruth Galdies,Wilfred F. J. van IJcken,Zeliha Ozgur,Nynke Gillemans,Jun Hou,Marisa Bugeja,Marisa Bugeja,Frank Grosveld,Marieke von Lindern,Alex E. Felice,Alex E. Felice,George P. Patrinos,Sjaak Philipsen +27 more
TL;DR: Functional assays suggested that, in addition to its established role in regulating adult globin expression, KLF1 is a key activator of the BCL11A gene, which encodes a suppressor of HbF expression.
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The miR-144/451 locus is required for erythroid homeostasis
Kasper D. Rasmussen,Salvatore Simmini,Cei Abreu-Goodger,Nenad Bartonicek,Monica Di Giacomo,Daniel Bilbao-Cortes,Rastislav Horos,Marieke von Lindern,Anton J. Enright,Dónal O'Carroll +9 more
TL;DR: The miR-144/451 cluster tunes gene expression to impart a robustness to erythropoiesis that is critical under conditions of stress, and shows that MiR-451 imparts a greater impact on target gene expression than miR -144.
Journal ArticleDOI
FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1
Walbert Bakker,Montserrat Blázquez-Domingo,Andrea Kolbus,Janey Besooyen,Peter Steinlein,Hartmut Beug,Paul J. Coffer,Bob Löwenberg,Marieke von Lindern,Thamar B. van Dijk +9 more
TL;DR: FoxO3a-controlled expression of BTG1 and subsequent regulation of protein arginine methyl transferase activity is proposed as a novel mechanism controlling erythroid expansion and differentiation.
Journal Article
Stem Cell Factor Receptor (c-KIT) Codon 816 Mutations Predict Development of Bilateral Testicular Germ-Cell Tumors
Leendert H. J. Looijenga,Hubert P. J. C. de Leeuw,Monique van Oorschot,Ruud J.H.L.M. van Gurp,Hans Stoop,Ad J. M. Gillis,Carlos A. de Gouveia Brazao,Rob F. A. Weber,Wim J. Kirkels,Thamar B. van Dijk,Marieke von Lindern,Peter J. M. Valk,Geczy Lajos,Edit Olah,Jahn M. Nesland,Sophie D. Fosså,J. Wolter Oosterhuis +16 more
TL;DR: It is concluded that somatic activating codon 816 c-KIT mutations are associated with development of bilateral TGCT and patients at risk for bilateral disease should undergo tailored treatment.