Pedro A. Perez-Mancera

TL;DR: It is found that frequent and diverse somatic aberrations in genes described traditionally as embryonic regulators of axon guidance, particularly SLIT/ROBO signalling, are also evident in murine Sleeping Beauty transposon-mediated somatic mutagenesis models of pancreatic cancer, providing further supportive evidence for the potential involvement ofAxon guidance genes in pancreatic carcinogenesis.

TL;DR: The protein coding exome is sequenced in a series of primary ccRCC and the identification of the SWI/SNF chromatin remodelling complex gene PBRM1 is reported as a second majorccRCC cancer gene, with truncating mutations in 41% (92/227) of cases.

TL;DR: Interestingly, it has been observed that supraphysiological expression of oncogenic Ras causes premature senescence, while endogenous expression of the endogenous Kras allele confers immortalization in primary murine cells, suggesting that the predominant biological systems previously used to evaluate onCogenic Ras may not reflect the true molecular or cellular properties of this oncogene.

TL;DR: In this article , the role of miRNAs in the activation of CAFs during the progression of PDAC and its response to therapy, as well as the potential role that PDAC-derived exosomal miRNA may play in activation of hepatic stellate cells (HSCs) and formation of liver metastasis.

TL;DR: It is reported that Scrib is indispensable for prostate homeostasis in mice and the observation that SCRIB deregulation strongly correlated with poor survival in human prostate cancer is suggested, suggesting that the polarity network could provide a new avenue for therapeutic intervention.