A
Amanda Mawson
Researcher at Garvan Institute of Medical Research
Publications - 23
Citations - 7728
Amanda Mawson is an academic researcher from Garvan Institute of Medical Research. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 15, co-authored 21 publications receiving 6216 citations. Previous affiliations of Amanda Mawson include University of New South Wales.
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Journal ArticleDOI
Genomic analyses identify molecular subtypes of pancreatic cancer
Peter Bailey,David K. Chang,Katia Nones,Katia Nones,Amber L. Johns,Ann-Marie Patch,Ann-Marie Patch,Marie-Claude Gingras,David Miller,David Miller,Angelika N. Christ,Timothy J. C. Bruxner,Michael C.J. Quinn,Michael C.J. Quinn,Craig Nourse,Craig Nourse,Murtaugh Lc,Ivon Harliwong,Senel Idrisoglu,Suzanne Manning,Ehsan Nourbakhsh,Shivangi Wani,Shivangi Wani,J. Lynn Fink,Oliver Holmes,Oliver Holmes,Chin,Matthew J. Anderson,Stephen H. Kazakoff,Stephen H. Kazakoff,Conrad Leonard,Conrad Leonard,Felicity Newell,Nicola Waddell,Scott Wood,Scott Wood,Qinying Xu,Qinying Xu,Peter J. Wilson,Nicole Cloonan,Nicole Cloonan,Karin S. Kassahn,Karin S. Kassahn,Karin S. Kassahn,Darrin Taylor,Kelly Quek,Alan J. Robertson,Lorena Pantano,Laura Mincarelli,Luis Navarro Sanchez,Lisa Evers,Jianmin Wu,Mark Pinese,Mark J. Cowley,Jones,Jones,Emily K. Colvin,Adnan Nagrial,Emily S. Humphrey,Lorraine A. Chantrill,Lorraine A. Chantrill,Amanda Mawson,Jeremy L. Humphris,Angela Chou,Angela Chou,Marina Pajic,Marina Pajic,Christopher J. Scarlett,Christopher J. Scarlett,Andreia V. Pinho,Marc Giry-Laterriere,Ilse Rooman,Jaswinder S. Samra,James G. Kench,James G. Kench,James G. Kench,Jessica A. Lovell,Neil D. Merrett,Christopher W. Toon,Krishna Epari,Nam Q. Nguyen,Andrew Barbour,Nikolajs Zeps,Kim Moran-Jones,Nigel B. Jamieson,Janet Graham,Janet Graham,Fraser Duthie,Karin A. Oien,Karin A. Oien,Hair J,Robert Grützmann,Anirban Maitra,Christine A. Iacobuzio-Donahue,Christopher L. Wolfgang,Richard A. Morgan,Rita T. Lawlor,Corbo,Claudio Bassi,Borislav Rusev,Paola Capelli,Roberto Salvia,Giampaolo Tortora,Debabrata Mukhopadhyay,Gloria M. Petersen,Munzy Dm,William E. Fisher,Saadia A. Karim,Eshleman,Ralph H. Hruban,Christian Pilarsky,Jennifer P. Morton,Owen J. Sansom,Aldo Scarpa,Elizabeth A. Musgrove,Ulla-Maja Bailey,Oliver Hofmann,Oliver Hofmann,R. L. Sutherland,David A. Wheeler,Anthony J. Gill,Anthony J. Gill,Richard A. Gibbs,John V. Pearson,John V. Pearson,Andrew V. Biankin,Sean M. Grimmond,Sean M. Grimmond,Sean M. Grimmond +128 more
TL;DR: Detailed genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32 recurrently mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH, ROBO/SLIT signalling, G1/S transition, SWI-SNF, chromatin modification, DNA repair and RNA processing.
Journal ArticleDOI
Whole genomes redefine the mutational landscape of pancreatic cancer.
Nicola Waddell,Marina Pajic,Ann-Marie Patch,David K. Chang,Karin S. Kassahn,Peter Bailey,Amber L. Johns,David Miller,Katia Nones,Kelly Quek,Michael C.J. Quinn,Alan J. Robertson,Muhammad Zaki Hidayatullah Fadlullah,Timothy J. C. Bruxner,Angelika N. Christ,Ivon Harliwong,Senel Idrisoglu,Suzanne Manning,Craig Nourse,Ehsan Nourbakhsh,Shivangi Wani,Peter J. Wilson,Emma Markham,Nicole Cloonan,Matthew J. Anderson,J. Lynn Fink,Oliver Holmes,Stephen H. Kazakoff,Conrad Leonard,Felicity Newell,Barsha Poudel,Sarah Song,Darrin Taylor,Nick Waddell,Scott Wood,Qinying Xu,Jianmin Wu,Mark Pinese,Mark J. Cowley,Hong C. Lee,Marc D. Jones,Adnan Nagrial,Jeremy L. Humphris,Lorraine A. Chantrill,Venessa T. Chin,Angela Steinmann,Amanda Mawson,Emily S. Humphrey,Emily K. Colvin,Angela Chou,Christopher J. Scarlett,Andreia V. Pinho,Marc Giry-Laterriere,Ilse Rooman,Jaswinder S. Samra,James G. Kench,Jessica A. Pettitt,Neil D. Merrett,Christopher W. Toon,Krishna Epari,Nam Q. Nguyen,Andrew Barbour,Nikolajs Zeps,Nigel B. Jamieson,Janet Graham,Simone P. Niclou,Rolf Bjerkvig,Robert Grützmann,Daniela Aust,Ralph H. Hruban,Anirban Maitra,Christine A. Iacobuzio-Donahue,Christopher L. Wolfgang,Richard A. Morgan,Rita T. Lawlor,Vincenzo Corbo,Claudio Bassi,Massimo Falconi,Giuseppe Zamboni,Giampaolo Tortora,Margaret A. Tempero,Anthony J. Gill,James R. Eshleman,Christian Pilarsky,Aldo Scarpa,Elizabeth A. Musgrove,John V. Pearson,Andrew V. Biankin,Sean M. Grimmond +88 more
TL;DR: Genomic instability co-segregated with inactivation of DNA maintenance genes (BRCA1, BRCA2 or PALB2) and a mutational signature of DNA damage repair deficiency, and 4 of 5 individuals with these measures of defective DNA maintenance responded to platinum therapy.
Journal ArticleDOI
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
Andrew V. Biankin,Andrew V. Biankin,Andrew V. Biankin,Nicola Waddell,Karin S. Kassahn,Marie-Claude Gingras,Lakshmi Muthuswamy,Amber L. Johns,David Miller,Peter Wilson,Ann-Marie Patch,Jianmin Wu,David K. Chang,David K. Chang,David K. Chang,Mark J. Cowley,Brooke Gardiner,Sarah Song,Ivon Harliwong,Senel Idrisoglu,Craig Nourse,Ehsan Nourbakhsh,Suzanne Manning,Shivangi Wani,Milena Gongora,Marina Pajic,Christopher J. Scarlett,Christopher J. Scarlett,Anthony J. Gill,Anthony J. Gill,Anthony J. Gill,Andreia V. Pinho,Ilse Rooman,Matthew J. Anderson,Oliver Holmes,Conrad Leonard,Darrin Taylor,Scott Wood,Qinying Xu,Katia Nones,J. Lynn Fink,Angelika N. Christ,Timothy J. C. Bruxner,Nicole Cloonan,Gabriel Kolle,Felicity Newell,Mark Pinese,R. Scott Mead,R. Scott Mead,Jeremy L. Humphris,Warren Kaplan,Marc D. Jones,Emily K. Colvin,Adnan Nagrial,Emily S. Humphrey,Angela Chou,Angela Chou,Venessa T. Chin,Lorraine A. Chantrill,Amanda Mawson,Jaswinder S. Samra,James G. Kench,James G. Kench,James G. Kench,Jessica A. Lovell,Roger J. Daly,Neil D. Merrett,Neil D. Merrett,Christopher W. Toon,Krishna Epari,Nam Q. Nguyen,Andrew Barbour,Nikolajs Zeps,Nipun Kakkar,Fengmei Zhao,Yuan Qing Wu,Min Wang,Donna M. Muzny,William E. Fisher,F. Charles Brunicardi,Sally E. Hodges,Jeffrey G. Reid,Jennifer Drummond,Kyle Chang,Yi Han,Lora Lewis,Huyen Dinh,Christian J. Buhay,Timothy Beck,Lee Timms,Michelle Sam,Kimberly Begley,Andrew M.K. Brown,Deepa Pai,Ami Panchal,Nicholas Buchner,Richard de Borja,Robert E. Denroche,Christina K. Yung,Stefano Serra,Nicole Onetto,Debabrata Mukhopadhyay,Ming-Sound Tsao,Patricia Shaw,Gloria M. Petersen,Steven Gallinger,Steven Gallinger,Ralph H. Hruban,Anirban Maitra,Christine A. Iacobuzio-Donahue,Richard D. Schulick,Christopher L. Wolfgang,Richard A. Morgan,Rita T. Lawlor,Paola Capelli,Vincenzo Corbo,Maria Scardoni,Giampaolo Tortora,Margaret A. Tempero,Karen M. Mann,Nancy A. Jenkins,Pedro A. Perez-Mancera,David J. Adams,David A. Largaespada,Lodewyk F. A. Wessels,Alistair G. Rust,Lincoln Stein,David A. Tuveson,Neal G. Copeland,Elizabeth A. Musgrove,Elizabeth A. Musgrove,Aldo Scarpa,James R. Eshleman,Thomas J. Hudson,Robert L. Sutherland,Robert L. Sutherland,David A. Wheeler,John V. Pearson,John Douglas Mcpherson,Richard A. Gibbs,Sean M. Grimmond +140 more
TL;DR: It is found that frequent and diverse somatic aberrations in genes described traditionally as embryonic regulators of axon guidance, particularly SLIT/ROBO signalling, are also evident in murine Sleeping Beauty transposon-mediated somatic mutagenesis models of pancreatic cancer, providing further supportive evidence for the potential involvement ofAxon guidance genes in pancreatic carcinogenesis.
Journal ArticleDOI
Whole-genome landscape of pancreatic neuroendocrine tumours
Aldo Scarpa,David K. Chang,Katia Nones,Katia Nones,Vincenzo Corbo,Ann-Marie Patch,Ann-Marie Patch,Peter Bailey,Peter Bailey,Rita T. Lawlor,Amber L. Johns,David Miller,Andrea Mafficini,Borislav Rusev,Maria Scardoni,Davide Antonello,Stefano Barbi,Katarzyna O. Sikora,Sara Cingarlini,Caterina Vicentini,Skye McKay,Michael C.J. Quinn,Michael C.J. Quinn,Timothy J. C. Bruxner,Angelika N. Christ,Ivon Harliwong,Senel Idrisoglu,Suzanne McLean,Craig Nourse,Craig Nourse,Ehsan Nourbakhsh,Peter J. Wilson,Matthew J. Anderson,J. Lynn Fink,Felicity Newell,Felicity Newell,Nick Waddell,Oliver Holmes,Oliver Holmes,Stephen H. Kazakoff,Stephen H. Kazakoff,Conrad Leonard,Conrad Leonard,Scott Wood,Scott Wood,Qinying Xu,Qinying Xu,Shivashankar H. Nagaraj,Eliana Amato,Irene Dalai,Samantha Bersani,Ivana Cataldo,Angelo Paolo Dei Tos,Paola Capelli,Maria Vittoria Davì,Luca Landoni,Anna Malpaga,Marco Miotto,Vicki L. J. Whitehall,Vicki L. J. Whitehall,Barbara A. Leggett,Barbara A. Leggett,Barbara A. Leggett,Janelle L. Harris,Jonathan M. Harris,Marc D. Jones,Jeremy L. Humphris,Lorraine A. Chantrill,Venessa T. Chin,Adnan Nagrial,Marina Pajic,Christopher J. Scarlett,Christopher J. Scarlett,Andreia V. Pinho,Ilse Rooman,Christopher W. Toon,Jianmin Wu,Jianmin Wu,Mark Pinese,Mark J. Cowley,Andrew Barbour,Amanda Mawson,Emily S. Humphrey,Emily K. Colvin,Angela Chou,Angela Chou,Jessica A. Lovell,Nigel B. Jamieson,Nigel B. Jamieson,Fraser Duthie,Marie-Claude Gingras,Marie-Claude Gingras,William E. Fisher,Rebecca A. Dagg,Loretta Lau,Michael Lee,Hilda A. Pickett,Roger R. Reddel,Jaswinder S. Samra,Jaswinder S. Samra,James G. Kench,James G. Kench,James G. Kench,Neil D. Merrett,Neil D. Merrett,Krishna Epari,Nam Q. Nguyen,Nikolajs Zeps,Nikolajs Zeps,Massimo Falconi,Michele Simbolo,Giovanni Butturini,George Van Buren,Stefano Partelli,Matteo Fassan,Kum Kum Khanna,Anthony J. Gill,Anthony J. Gill,David A. Wheeler,Richard A. Gibbs,Elizabeth A. Musgrove,Claudio Bassi,Giampaolo Tortora,Paolo Pederzoli,John V. Pearson,John V. Pearson,Nicola Waddell,Nicola Waddell,Andrew V. Biankin,Sean M. Grimmond +129 more
TL;DR: In this paper, the authors performed whole-genome sequencing of 102 primary pancreatic neuroendocrine tumours and defined the genomic events that characterize their pathogenesis, including a deficiency in G:C,>T:A base excision repair due to inactivation of MUTYH, which encodes a DNA glycosylase.
Journal ArticleDOI
Hypermutation In Pancreatic Cancer
Jeremy L. Humphris,Ann-Marie Patch,Ann-Marie Patch,Katia Nones,Katia Nones,Peter Bailey,Peter Bailey,Amber L. Johns,Skye McKay,David K. Chang,David Miller,David Miller,Marina Pajic,Marina Pajic,Karin S. Kassahn,Karin S. Kassahn,Michael C.J. Quinn,Michael C.J. Quinn,Timothy J. C. Bruxner,Angelika N. Christ,Ivon Harliwong,Senel Idrisoglu,Suzanne Manning,Craig Nourse,Craig Nourse,Ehsan Nourbakhsh,Andrew Stone,Peter J. Wilson,Matthew J. Anderson,J. Lynn Fink,Oliver Holmes,Oliver Holmes,Stephen H. Kazakoff,Stephen H. Kazakoff,Conrad Leonard,Conrad Leonard,Felicity Newell,Felicity Newell,Nick Waddell,Scott Wood,Scott Wood,Ronald S Mead,Qinying Xu,Qinying Xu,Jianmin Wu,Mark Pinese,Mark J. Cowley,Mark J. Cowley,Marc D. Jones,Marc D. Jones,Adnan Nagrial,Venessa T. Chin,Lorraine A. Chantrill,Lorraine A. Chantrill,Amanda Mawson,Angela Chou,Angela Chou,Christopher J. Scarlett,Christopher J. Scarlett,Andreia V. Pinho,Ilse Rooman,Marc Giry-Laterriere,Jaswinder S. Samra,Jaswinder S. Samra,James G. Kench,James G. Kench,James G. Kench,Neil D. Merrett,Christopher W. Toon,Krishna Epari,Nam Q. Nguyen,Andrew Barbour,Nikolajs Zeps,Nigel B. Jamieson,Nigel B. Jamieson,Colin J. McKay,C. Ross Carter,Euan J. Dickson,Janet Graham,Janet Graham,Fraser Duthie,Karin A. Oien,Jane Hair,Jennifer P. Morton,Owen J. Sansom,Robert Grützmann,Ralph H. Hruban,Anirban Maitra,Christine A. Iacobuzio-Donahue,Richard D. Schulick,Christopher L. Wolfgang,Richard A. Morgan,Rita T. Lawlor,Borislav Rusev,Vincenzo Corbo,Roberto Salvia,Ivana Cataldo,Giampaolo Tortora,Margaret A. Tempero,Oliver Hofmann,James R. Eshleman,Christian Pilarsky,Aldo Scarpa,Elizabeth A. Musgrove,Elizabeth A. Musgrove,Elizabeth A. Musgrove,Anthony J. Gill,Anthony J. Gill,Anthony J. Gill,John V. Pearson,John V. Pearson,Sean M. Grimmond,Sean M. Grimmond,Nicola Waddell,Nicola Waddell,Andrew V. Biankin +115 more
TL;DR: Defining mutation load in individual pancreatic cancers and the optimal assay for patient selection may inform clinical trial design for immunotherapy in pancreatic cancer.