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Waraporn Chan-on
Researcher at National University of Singapore
Publications - 9
Citations - 2280
Waraporn Chan-on is an academic researcher from National University of Singapore. The author has contributed to research in topics: Exome sequencing & Exome. The author has an hindex of 6, co-authored 8 publications receiving 2041 citations. Previous affiliations of Waraporn Chan-on include Khon Kaen University & National Center for Charitable Statistics.
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Journal ArticleDOI
Exome sequencing identifies frequent mutation of the SWI/SNF Complex Gene PBRM1 in renal carcinoma
Ignacio Varela,Patrick S. Tarpey,Keiran Raine,Dachuan Huang,Choon Kiat Ong,Philip J. Stephens,Helen Davies,David T. Jones,Meng-Lay Lin,Jon W. Teague,Graham R. Bignell,Adam Butler,Juok Cho,Gillian L. Dalgliesh,Danushka Galappaththige,Christopher Greenman,Claire Hardy,Mingming Jia,Calli Latimer,King Wai Lau,John Marshall,Stuart McLaren,Andrew Menzies,Laura Mudie,Lucy Stebbings,David A. Largaespada,Lodewyk F. A. Wessels,Stéphane Richard,Stéphane Richard,Richard J. Kahnoski,John Anema,David A. Tuveson,Pedro A. Perez-Mancera,Ville Mustonen,Andrej Fischer,Andrej Fischer,David J. Adams,Alistair G. Rust,Waraporn Chan-on,Chutima Subimerb,Karl Dykema,Kyle A. Furge,Peter J. Campbell,Bin Tean Teh,Bin Tean Teh,Michael R. Stratton,P. Andrew Futreal +46 more
TL;DR: The protein coding exome is sequenced in a series of primary ccRCC and the identification of the SWI/SNF chromatin remodelling complex gene PBRM1 is reported as a second majorccRCC cancer gene, with truncating mutations in 41% (92/227) of cases.
Journal ArticleDOI
Exome sequencing of liver fluke–associated cholangiocarcinoma
Choon Kiat Ong,Chutima Subimerb,Chutima Subimerb,Chawalit Pairojkul,Sopit Wongkham,Ioana Cutcutache,Willie Yu,John R. McPherson,George E. Allen,Cedric Chuan Young Ng,Bernice Huimin Wong,Swe Swe Myint,Vikneswari Rajasegaran,Hong Lee Heng,Anna Gan,Zhi Jiang Zang,Yingting Wu,Yingting Wu,Jeanie Wu,Ming Hui Lee,Dachuan Huang,Pauline Ong,Waraporn Chan-on,Waraporn Chan-on,Yun Cao,Chao Nan Qian,Kiat Hon Lim,Aikseng Ooi,Karl Dykema,Kyle A. Furge,Veerapol Kukongviriyapan,Banchob Sripa,Chaisiri Wongkham,Puangrat Yongvanit,P. Andrew Futreal,Vajarabhongsa Bhudhisawasdi,Steve Rozen,Patrick Tan,Patrick Tan,Bin Tean Teh +39 more
TL;DR: Insight into the mutational landscape contributing to O. viverrini–related CCA is provided and 206 somatic mutations in 187 genes using Sanger sequencing are identified and selected 15 genes for mutation prevalence screening in an additional 46 individuals with CCA.
Journal ArticleDOI
Exome sequencing identifies distinct mutational patterns in liver fluke–related and non-infection-related bile duct cancers
Waraporn Chan-on,Waraporn Chan-on,Maarja-Liisa Nairismagi,Choon Kiat Ong,Weng Khong Lim,Simona Dima,Chawalit Pairojkul,Kiat Hon Lim,John R. McPherson,Ioana Cutcutache,Hong Lee Heng,London L.P.J. Ooi,Alexander Y. F. Chung,Pierce K. H. Chow,Peng Chung Cheow,Ser Yee Lee,Su Pin Choo,Iain Beehuat Tan,Dan G. Duda,Anca Nastase,Swe Swe Myint,Bernice Huimin Wong,Anna Gan,Vikneswari Rajasegaran,Cedric Chuan Young Ng,Sanjanaa Nagarajan,Apinya Jusakul,Shenli Zhang,Priya Vohra,Willie Yu,Dachuan Huang,Paiboon Sithithaworn,Puangrat Yongvanit,Sopit Wongkham,Narong Khuntikeo,Vajaraphongsa Bhudhisawasdi,Irinel Popescu,Steven G. Rozen,Patrick Tan,Patrick Tan,Bin Tean Teh +40 more
TL;DR: Functional studies demonstrated tumor suppressive functions for BAP1 and ARID1A, establishing the role of chromatin modulators in CCA pathogenesis and indicating that different causative etiologies may induce distinct somatic alterations, even within the same tumor type.
Journal ArticleDOI
Genome-Wide Mutational Signatures of Aristolochic Acid and Its Application as a Screening Tool
Song Ling Poon,Song Ling Poon,See Tong Pang,John R. McPherson,Willie Yu,Willie Yu,Kie Kyon Huang,Peiyong Guan,Wen-Hui Weng,Ee Yan Siew,Ee Yan Siew,Yujing Liu,Hong Lee Heng,Hong Lee Heng,Soo Ching Chong,Soo Ching Chong,Anna Gan,Anna Gan,Su Ting Tay,Weng Khong Lim,Weng Khong Lim,Ioana Cutcutache,Dachuan Huang,Dachuan Huang,Lian Dee Ler,Lian Dee Ler,Maarja-Liisa Nairismagi,Maarja-Liisa Nairismagi,Ming Hui Lee,Ying Hsu Chang,Kai Jie Yu,Waraporn Chan-on,Waraporn Chan-on,Bin Kui Li,Yunfei Yuan,Chao Nan Qian,Kwai Fong Ng,Ching Fang Wu,Cheng Lung Hsu,Ralph M. Bunte,Michael R. Stratton,P. Andrew Futreal,Wing-Kin Sung,Wing-Kin Sung,Cheng-Keng Chuang,Choon Kiat Ong,Choon Kiat Ong,Steven G. Rozen,Steven G. Rozen,Patrick Tan,Bin Tean Teh,Bin Tean Teh +51 more
TL;DR: A “molecular signature” of AA-induced DNA damage is presented, which helps to explain the mutagenic effects of AA and may also be useful as a way to detect unsuspected AA exposure as a cause of cancer.
Journal ArticleDOI
First somatic mutation of E2F1 in a critical DNA binding residue discovered in well-differentiated papillary mesothelioma of the peritoneum
Willie Yu,Willie Yu,Waraporn Chan-on,Waraporn Chan-on,Melissa Ching Ching Teo,Choon Kiat Ong,Choon Kiat Ong,Ioana Cutcutache,George E. Allen,George E. Allen,Bernice Wong,Bernice Wong,Swe Swe Myint,Swe Swe Myint,Kiat Hon Lim,P. Mathijs Voorhoeve,Steve Rozen,Khee Chee Soo,Patrick Tan,Patrick Tan,Bin Tean Teh,Bin Tean Teh,Bin Tean Teh +22 more
TL;DR: The R166H mutation in E2F1 is shown to have a deleterious effect on its DNA binding ability as well as increasing its stability and subsequent accumulation in R166h mutant cells.