P
Peidong Han
Researcher at Peking University
Publications - 20
Citations - 1660
Peidong Han is an academic researcher from Peking University. The author has contributed to research in topics: Zebrafish & Regeneration (biology). The author has an hindex of 14, co-authored 19 publications receiving 1464 citations. Previous affiliations of Peidong Han include University of California & University of California, Los Angeles.
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Journal ArticleDOI
Superoxide Flashes in Single Mitochondria
Wang Wang,Huaqiang Fang,Linda Groom,Aiwu Cheng,Wanrui Zhang,Jie Liu,Xianhua Wang,Kaitao Li,Peidong Han,Ming Zheng,Jinhu Yin,Weidong Wang,Mark P. Mattson,Joseph P. Y. Kao,Edward G. Lakatta,Shey-Shing Sheu,Kunfu Ouyang,Ju Chen,Robert T. Dirksen,Heping Cheng +19 more
TL;DR: It is shown that individual mitochondria undergo spontaneous bursts of superoxide generation, termed "superoxide flashes", and proposed that superoxide flashes could serve as a valuable biomarker for a wide variety of oxidative stress-related diseases.
Journal ArticleDOI
In vivo cardiac reprogramming contributes to zebrafish heart regeneration
Ruilin Zhang,Peidong Han,Hongbo Yang,Kunfu Ouyang,Derek Lee,Yi Fan Lin,Karen Ocorr,Guson Kang,Ju Chen,Didier Y.R. Stainier,Didier Y.R. Stainier,Deborah Yelon,Neil C. Chi,Neil C. Chi +13 more
TL;DR: These studies not only provide evidence for the plasticity of cardiac lineages during myocardial injury, but more importantly reveal an abundant new potential cardiac resident cellular source for cardiac ventricular regeneration.
Journal ArticleDOI
Cardioprotection of Ischemia/Reperfusion Injury by Cholesterol-Dependent MG53-Mediated Membrane Repair
Xianhua Wang,Wenjun Xie,Yi Zhang,Pei-Hui Lin,Liang Han,Peidong Han,Yanru Wang,Zheng Chen,Guangju Ji,Ming Zheng,Noah Weisleder,Rui-Ping Xiao,Hiroshi Takeshima,Jianjie Ma,Heping Cheng +14 more
TL;DR: It is demonstrated that cholesterol-dependent MG53-mediated cardiac membrane repair is a vital, heretofore unappreciated cardioprotective mechanism against a multitude of insults and may bear important therapeutic implications.
Journal ArticleDOI
Hydrogen peroxide primes heart regeneration with a derepression mechanism
Peidong Han,Xiao-Hai Zhou,Nannan Chang,Chenglu Xiao,Shouyu Yan,He Ren,Xin-Zhuang Yang,Meiling Zhang,Qing Wu,Boyang Tang,Ju-Peng Diao,Xiaojun Zhu,Chuanmao Zhang,Chuan-Yun Li,Heping Cheng,Jing-Wei Xiong +15 more
TL;DR: It is concluded that H2O2 potentially generated from Duox/Nox2 promotes heart regeneration in zebrafish by unleashing MAP kinase signaling through a derepression mechanism involving Dusp6.
Journal ArticleDOI
Rad As a Novel Regulator of Excitation–Contraction Coupling and β-Adrenergic Signaling in Heart
Gang Wang,Xiaojun Zhu,Wenjun Xie,Peidong Han,Kaitao Li,Zhongcui Sun,Yanru Wang,Chunlei Chen,Ruisheng Song,Chun-Mei Cao,Jifeng Zhang,Caihong Wu,Jie Liu,Heping Cheng +13 more
TL;DR: Rad is established as a novel endogenous regulator of cardiac EC coupling and &bgr;AR signaling and support a parsimonious model in which Rad buffers Cav&b gr; to modulate LCC activity, EC coupling, and andb Gr;AR responsiveness.