C
Chaker N. Adra
Researcher at Brigham and Women's Hospital
Publications - 59
Citations - 3685
Chaker N. Adra is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Gene & Atopy. The author has an hindex of 30, co-authored 59 publications receiving 3481 citations. Previous affiliations of Chaker N. Adra include Harvard University & Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
Genetic variants of IL-13 signalling and human asthma and atopy
Andrea Heinzmann,X. Q. Mao,Mina Akaiwa,R. T. Kreomer,Peisong Gao,Koichi Ohshima,R. Umeshita,R. Umeshita,Yoshito Abe,Sandra Braun,Tetsuji Yamashita,Mark H. Roberts,Rie Sugimoto,Kazuhiko Arima,Yojiro Arinobu,Bin Yu,S. Kruse,Tadao Enomoto,Y. Dake,M. Kawai,S. Shimazu,S. Sasaki,Chaker N. Adra,M. Kitaichi,Hiroshi Inoue,Kohei Yamauchi,Nobukazu Tomichi,Fumihiko Kurimoto,Naotaka Hamasaki,Julian M. Hopkin,Kenji Izuhara,T. Shirakawa,Klaus A. Deichmann +32 more
TL;DR: Detailed molecular modelling analyses indicate that residue 110 of IL-13, the site of the charge-modifying variants Arg and Gln, is important in the internal constitution of the ligand and crucial in ligand-receptor interaction, likely to be important promoters of human asthma.
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Immunomodulation by Mesenchymal Stem Cells A Potential Therapeutic Strategy for Type 1 Diabetes
TL;DR: Recent advances that have broadened the understanding of the immunomodulatory properties of MSC are focused on and insight is provided as to their potential for clinical use as a cell-based therapy for immune-mediated disorders and, in particular, type 1 diabetes.
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Immunomodulatory function of bone marrow-derived mesenchymal stem cells in experimental autoimmune type 1 diabetes.
Paolo Fiorina,Mollie Jurewicz,Andrea Augello,Andrea Vergani,Shirine Dada,Stefano La Rosa,Martin K. Selig,Jonathan G. Godwin,Kenneth Law,Claudia Placidi,R. Neal Smith,Carlo Capella,Scott J. Rodig,Chaker N. Adra,Mark A. Atkinson,Mohamed H. Sayegh,Reza Abdi +16 more
TL;DR: Bone marrow-derived murine MSC is characterized for their ability to modulate immune responses in the context of type 1 diabetes, as represented in NOD mice, to provide important preclinical data supporting the basis for further development of allogeneic MSC-based therapies for T1D and, potentially, for other autoimmune disorders.
Journal ArticleDOI
Atopy and asthma: genetic variants of IL-4 and IL-13 signalling
TL;DR: Genetic variants of IL-4/IL-13 signalling are discussed, and whether they promote asthma or atopy among different ethnic groups are discussed.
Journal ArticleDOI
A TRPV2-PKA signaling module for transduction of physical stimuli in mast cells.
Alexander J. Stokes,Lori M. N. Shimoda,Murielle Koblan-Huberson,Chaker N. Adra,Helen Turner,Helen Turner +5 more
TL;DR: A novel protein kinase A (PKA)–dependent signaling module, containing PKA and a putative A kinase adapter protein, Acyl CoA binding domain protein (ACBD)3, that interacts with TRPV2 in mast cells is described and it is proposed that regulated phosphorylation by PKA may be a common pathway forTRPV modulation.