Naotaka Hamasaki

TL;DR: It is hypothesized that ROS may induce mitochondrial DNA (mtDNA) damage, which leads to defects of mtDNA-encoded gene expression and respiratory chain complex enzymes and thus may contribute to the progression of left ventricular remodeling and failure after myocardial infarction.

TL;DR: Detailed molecular modelling analyses indicate that residue 110 of IL-13, the site of the charge-modifying variants Arg and Gln, is important in the internal constitution of the ligand and crucial in ligand-receptor interaction, likely to be important promoters of human asthma.

TL;DR: Results indicate that the Y595C and the K155E mutations are responsible for a secretion defect and a decreased anticoagulant activity of PS, respectively.

TL;DR: It is found that the hydrophobic length of TM1 was critical for membrane insertion and that formation of a transport-active structure also depended on the presence of specific amino acid sequences in TM1.

TL;DR: Congenital afibrinogenemia due to a novel homozygous nonsense mutation of the fibrinagen gamma-chain gene, fibr inogen Hakata, was found in an 18-year-old Japanese girl who had received supplemental fibrInogen therapy since she was 4 months old.