P
Pelin Uluocak
Researcher at University of Oxford
Publications - 8
Citations - 1023
Pelin Uluocak is an academic researcher from University of Oxford. The author has contributed to research in topics: Cohesin & Establishment of sister chromatid cohesion. The author has an hindex of 2, co-authored 8 publications receiving 917 citations. Previous affiliations of Pelin Uluocak include Research Institute of Molecular Pathology.
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Journal ArticleDOI
Building Sister Chromatid Cohesion: Smc3 Acetylation Counteracts an Antiestablishment Activity
Benjamin D. Rowland,Maurici B. Roig,Tatsuya Nishino,Alexander Kurze,Pelin Uluocak,Ajay Kumar Mishra,Frédéric Beckouët,Philippa Underwood,Jean Metson,Richard Imre,Karl Mechtler,Vittorio L. Katis,Kim Nasmyth +12 more
TL;DR: In the absence of Eco1, an acetyl transferase normally essential for establishing sister chromatid cohesion, Scc3, Pds5, and Rad61 (Wapl) mutations were introduced in this paper.
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Closing the cohesin ring: Structure and function of its Smc3-kleisin interface
Thomas G. Gligoris,Johanna C. Scheinost,Frank Bürmann,Naomi J Petela,Kok-Lung Chan,Kok-Lung Chan,Pelin Uluocak,Frédéric Beckouët,Stephan Gruber,Kim Nasmyth,Jan Löwe +10 more
TL;DR: It is shown here that the N-terminal domain of yeast Scc1 contains two α helices, forming a four-helix bundle with the coiled coil emerging from Smc3’s adenosine triphosphatase head, indicating that the cohesin ring must indeed encircle the two DNA strands to hold them together.
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An Smc3 acetylation cycle is essential for establishment of sister chromatid cohesion.
Frédéric Beckouët,Bin Hu,Maurici B. Roig,Takashi Sutani,Makiko Komata,Pelin Uluocak,Vittorio L. Katis,Katsuhiko Shirahige,Kim Nasmyth +8 more
TL;DR: By inducing Smc3 deacetylation in postreplicative cells due to Hos1 overexpression, this work provides evidence that Smc 3 acetylation contributes to the maintenance of sister chromatid cohesion.
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PP2A-B56 opposes Mps1 phosphorylation of Knl1 and thereby promotes spindle assembly checkpoint silencing
Antonio Espert,Pelin Uluocak,Ricardo Nunes Bastos,Davinderpreet Mangat,Philipp Graab,Ulrike Gruneberg +5 more
TL;DR: The kinetochore surveillance phosphatase PP2A-B56 dephosphorylates Knl1 to silence the spindle assembly checkpoint after all chromosomes have been correctly attached to microtubules.
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Cohesin's Concatenation of Sister DNAs Maintains Their Intertwining
TL;DR: It is concluded that by retarding Topo II-driven decatenation, cohesin mediates sister chromatid cohesion by an indirect mechanism as well as one involving entrapment of sister DNAs inside its tripartite ring.