P
Pentao Liu
Researcher at Li Ka Shing Faculty of Medicine, University of Hong Kong
Publications - 153
Citations - 13957
Pentao Liu is an academic researcher from Li Ka Shing Faculty of Medicine, University of Hong Kong. The author has contributed to research in topics: Induced pluripotent stem cell & Stem cell. The author has an hindex of 52, co-authored 138 publications receiving 12137 citations. Previous affiliations of Pentao Liu include Wellcome Trust Sanger Institute & National Institutes of Health.
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Journal ArticleDOI
A recombineering based approach for high-throughput conditional knockout targeting vector construction
Waiin Chan,Nina Costantino,Ruixue Li,Song Choon Lee,Qin Su,David Melvin,Donald L. Court,Pentao Liu +7 more
TL;DR: A new recombineering system is described that makes it a reality to generate large numbers of precisely engineered DNA constructs for functional genomics studies, and is able to construct 96 conditional knockout targeting vectors simultaneously.
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A genome-wide, end-sequenced 129Sv BAC library resource for targeting vector construction
David J. Adams,Michael A. Quail,Tony Cox,Louise van der Weyden,Barbara D. Gorick,Qin Su,Wei In Chan,Robert L. Davies,James K. Bonfield,Frances Law,Sean Humphray,Bob Plumb,Pentao Liu,Jane Rogers,Allan Bradley +14 more
TL;DR: It is shown that targeting vectors containing DNA recombineered from this BAC library can be used to target genes efficiently in several 129-derived ES cell lines.
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Bcl11b is essential for group 2 innate lymphoid cell development
Jennifer A. Walker,Christopher J. Oliphant,Alexandros Englezakis,Yong Yu,Simon Clare,Hans Reimer Rodewald,Gabrielle T. Belz,Pentao Liu,Padraic G. Fallon,Andrew N. J. McKenzie +9 more
TL;DR: Mice deficient in Bcl11b exhibit a lack of ILC2 development and an expansion of RORγt+ ILC3s and are unable to clear Nippostrongylus brasiliensis worm infection, but can clear Citrobacter rodentium.
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The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development
Yong Yu,Cui Wang,Simon Clare,Juexuan Wang,Song Choon Lee,Cordelia Brandt,Shannon Burke,Liming Lu,Liming Lu,Daqian He,Nancy A. Jenkins,Neal G. Copeland,Gordon Dougan,Pentao Liu +13 more
TL;DR: It is demonstrated that the transcription factor Bcl11b is specifically expressed in mouse innate lymphoid progenitors committed to the ILC2 lineage and is required for their development.
Journal ArticleDOI
LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease
Dean S. Griffiths,Juan Li,Mark A. Dawson,Mark A. Dawson,Matthew Trotter,Yi-Han Cheng,Aileen M. Smith,William Mansfield,Pentao Liu,Tony Kouzarides,Jennifer Nichols,Andrew J. Bannister,Anthony R. Green,Berthold Göttgens +13 more
TL;DR: Results uncover a previously unrecognized role for direct signalling to chromatin by JAK2 as an important mediator of ES cell self-renewal.