P
Per Øystein Sakariassen
Researcher at University of Bergen
Publications - 29
Citations - 3212
Per Øystein Sakariassen is an academic researcher from University of Bergen. The author has contributed to research in topics: Glioma & Angiogenesis. The author has an hindex of 22, co-authored 29 publications receiving 2935 citations.
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Journal ArticleDOI
CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells.
Jian Wang,Per Øystein Sakariassen,Oleg Tsinkalovsky,Heike Immervoll,Heike Immervoll,Stig Ove Bøe,Agnete Svendsen,Lars Prestegarden,Gro V. Røsland,Frits Thorsen,Linda Elin Birkhaug Stuhr,Anders Molven,Anders Molven,Rolf Bjerkvig,Per Øyvind Enger +14 more
TL;DR: It is shown that CD133 negative glioma cells are tumorgenic in nude rats, and thatCD133 positive cells can be obtained from these tumors, suggesting that it may be involved during brain tumor progression.
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Glutamine Synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma
Saverio Tardito,Anais Oudin,Shafiq U. Ahmed,Fred Fack,Olivier Keunen,Liang Zheng,Hrvoje Miletic,Per Øystein Sakariassen,Adam Weinstock,Allon Wagner,Susan L. Lindsay,Andreas K. Hock,Susan C. Barnett,Eytan Ruppin,Svein H. Mørkve,Morten Lund-Johansen,Morten Lund-Johansen,Anthony J. Chalmers,Rolf Bjerkvig,Simone P. Niclou,Eyal Gottlieb +20 more
TL;DR: It is shown here that in glioblastoma (GBM) cells, almost half of the Gln-derived glutamate (Glu) is secreted and does not enter the TCA cycle, and that inhibiting glutaminolysis does not affect cell proliferation.
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Neural stem cell markers, nestin and musashi proteins, in the progression of human glioma: correlation of nestin with prognosis of patient survival.
TL;DR: The presented data links the invasive glioma cells to CNS precursor cells, indicating that the most malignant cells in the gliomas may well be closely related to theglioma stem cells.
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In vivo models of primary brain tumors: pitfalls and perspectives
Peter C. Huszthy,Inderjit Daphu,Simone P. Niclou,Daniel Stieber,Janice M. Nigro,Per Øystein Sakariassen,Hrvoje Miletic,Frits Thorsen,Rolf Bjerkvig +8 more
TL;DR: It is anticipated that a combined comprehensive knowledge of the various models currently available will provide important new knowledge on target identification and the validation and development of new therapeutic strategies.
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Angiogenesis-independent tumor growth mediated by stem-like cancer cells.
Per Øystein Sakariassen,Lars Prestegarden,Jian Wang,Kai-Ove Skaftnesmo,Rupavathana Mahesparan,Carla Molthoff,Peter Sminia,Eirik Sundlisæter,Anjan Misra,Berit B. Tysnes,Martha Chekenya,H. Peters,Gabriel Lende,Karl-Henning Kalland,Anne Margrete Øyan,Kjell Petersen,Inge Jonassen,Albert J. van der Kogel,Burt G. Feuerstein,A. Jorge A. Terzis,Rolf Bjerkvig,Per Øyvind Enger +21 more
TL;DR: The described angiogenesis-independent tumor growth and the uncoupling of invasion andAngiogenesis, represented by the stem-like cancer cells and the cells derived from them, respectively, point at two completely independent mechanisms that drive tumor progression.