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Anjan Misra
Researcher at St. Joseph's Hospital and Medical Center
Publications - 22
Citations - 4339
Anjan Misra is an academic researcher from St. Joseph's Hospital and Medical Center. The author has contributed to research in topics: Comparative genomic hybridization & Glioma. The author has an hindex of 15, co-authored 21 publications receiving 4056 citations. Previous affiliations of Anjan Misra include University of Lausanne & Barrow Neurological Institute.
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Journal ArticleDOI
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
Heidi S. Phillips,Samir Kharbanda,Ruihuan Chen,William F. Forrest,Robert Soriano,Thomas D. Wu,Anjan Misra,Janice Nigro,Howard Colman,Liliana Soroceanu,P. Mickey Williams,Zora Modrusan,Burt G. Feuerstein,Kenneth Aldape +13 more
TL;DR: Previously undescribed prognostic subclasses of high-grade astrocytoma are identified and discovered to resemble stages in neurogenesis, suggesting functional relevance of tumor subtype molecular signatures is suggested by the ability of cell line signatures to predict neurosphere growth.
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Integrated array-comparative genomic hybridization and expression array profiles identify clinically relevant molecular subtypes of glioblastoma
Janice Nigro,Anjan Misra,Li Zhang,Ivan Smirnov,Howard Colman,Chandi A. Griffin,Natalie C. Ozburn,Mingang Chen,Edward Pan,Dimpy Koul,W. K. Alfred Yung,Burt G. Feuerstein,Kenneth Aldape +12 more
TL;DR: The results indicate that integrating DNA and mRNA-based tumor profiles offers the potential for a clinically relevant classification more robust than either method alone and provides a basis for identifying genes important in glioma pathogenesis.
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Angiogenesis-independent tumor growth mediated by stem-like cancer cells.
Per Øystein Sakariassen,Lars Prestegarden,Jian Wang,Kai-Ove Skaftnesmo,Rupavathana Mahesparan,Carla Molthoff,Peter Sminia,Eirik Sundlisæter,Anjan Misra,Berit B. Tysnes,Martha Chekenya,H. Peters,Gabriel Lende,Karl-Henning Kalland,Anne Margrete Øyan,Kjell Petersen,Inge Jonassen,Albert J. van der Kogel,Burt G. Feuerstein,A. Jorge A. Terzis,Rolf Bjerkvig,Per Øyvind Enger +21 more
TL;DR: The described angiogenesis-independent tumor growth and the uncoupling of invasion andAngiogenesis, represented by the stem-like cancer cells and the cells derived from them, respectively, point at two completely independent mechanisms that drive tumor progression.
Journal ArticleDOI
Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors.
Giuseppe Zardo,Maarit Tiirikainen,Chibo Hong,Anjan Misra,Burt G. Feuerstein,Stanislav Volik,Colin Collins,Kathleen R. Lamborn,Andrew W. Bollen,Daniel Pinkel,Donna G. Albertson,Joseph F. Costello +11 more
TL;DR: The results show that most aberrant methylation events are focal and independent of deletions, and the rare convergence of these mechanisms can pinpoint biallelic gene inactivation without the use of positional cloning.
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Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma.
Liliana Soroceanu,Samir Kharbanda,Ruihuan Chen,Robert Soriano,Kenneth Aldape,Anjan Misra,Jiping Zha,William F. Forrest,Janice Nigro,Zora Modrusan,Burt G. Feuerstein,Heidi S. Phillips +11 more
TL;DR: Evidence is provided that the IGF2–PIK3R3 signaling axis is involved in promoting the growth of a subclass of highly aggressive human GBMs that lack EGF receptor amplification and the importance of the phosphoinositide 3-kinase/Akt pathway for growth of high-grade gliomas is underscored.