Pere Santamaria

TL;DR: Evidence is provided that the short-term, combined effects of tryptophan deprivation and tryPTophan catabolites result in GCN2 kinase-dependent down-regulation of the TCR ζ-chain in murine CD8+ T cells.

TL;DR: Two-photon laser-scanning microscopy is used to analyze lymph node priming of diabetogenic T cells and to delineate the mechanisms of Treg cell control of autoimmunity in vivo, supporting the idea that dendritic cells are central to T Reg cell function in vivo.

TL;DR: It is revealed that the autoantigen targeted by a prevalent population of pathogenic CD8+ T cells in nonobese diabetic mice is islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), a new, potential target for diagnostic and therapeutic approaches.

TL;DR: Systemic delivery of nanoparticles coated with autoimmune-disease-relevant peptides bound to major histocompatibility complex class II (pMHCII) molecules triggers the generation and expansion of antigen-specific regulatory CD4+ T cell type 1 (TR1)-like cells in different mouse models, leading to resolution of established autoimmune phenomena.

TL;DR: It is shown that engineered haplodeficiency of Il2 gene expression not only reduces T cell IL-2 production by twofold but also mimics the autoimmune dysregulatory effects of the naturally occurring susceptibility alleles of Il1.