M
Maria C. Fioretti
Researcher at University of Perugia
Publications - 148
Citations - 11784
Maria C. Fioretti is an academic researcher from University of Perugia. The author has contributed to research in topics: Antigen & Cytotoxic T cell. The author has an hindex of 42, co-authored 148 publications receiving 11180 citations. Previous affiliations of Maria C. Fioretti include University of Padua.
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Journal ArticleDOI
Modulation of tryptophan catabolism by regulatory T cells.
Francesca Fallarino,Ursula Grohmann,Kwang Woo Hwang,Ciriana Orabona,Carmine Vacca,Roberta Bianchi,Maria Laura Belladonna,Maria C. Fioretti,Maria-Luisa Alegre,Paolo Puccetti +9 more
TL;DR: It is shown that mouse CD4+CD25+ cells, either resting or induced to overexpress CTLA-4 by treatment with antibody to CD3, initiated tryptophan catabolism in dendritic cells through a CT LA-4-dependent mechanism, which might represent a major mechanism of action of TR cells.
Journal ArticleDOI
CTLA-4-Ig regulates tryptophan catabolism in vivo.
Ursula Grohmann,Ciriana Orabona,Francesca Fallarino,Carmine Vacca,Filippo Calcinaro,Alberto Falorni,Paola Candeloro,Maria Laura Belladonna,Roberta Bianchi,Maria C. Fioretti,Paolo Puccetti +10 more
TL;DR: It is shown that long-term survival of pancreatic islet allografts induced by the soluble fusion protein CTLA-4–immunoglobulin (CTLA- 4–Ig) is contingent upon effective tryptophan catabolism in the host and that CTla-4 acts as a ligand for B7 receptor molecules that transduce intracellular signals.
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The Combined Effects of Tryptophan Starvation and Tryptophan Catabolites Down-Regulate T Cell Receptor ζ-Chain and Induce a Regulatory Phenotype in Naive T Cells
Francesca Fallarino,Ursula Grohmann,Sylvaine You,Barbara C. McGrath,Douglas R. Cavener,Carmine Vacca,Ciriana Orabona,Roberta Bianchi,Maria Laura Belladonna,Claudia Volpi,Pere Santamaria,Maria C. Fioretti,Paolo Puccetti +12 more
TL;DR: Evidence is provided that the short-term, combined effects of tryptophan deprivation and tryPTophan catabolites result in GCN2 kinase-dependent down-regulation of the TCR ζ-chain in murine CD8+ T cells.
Journal ArticleDOI
T cell apoptosis by tryptophan catabolism.
Francesca Fallarino,Ursula Grohmann,Carmine Vacca,Roberta Bianchi,Ciriana Orabona,Antonio Spreca,Maria C. Fioretti,Paolo Puccetti +7 more
TL;DR: It is shown that tryptophan metabolites in the kynurenine pathway, such as 3-hydroxyanthranilic and quinolinic acids, will induce the selective apoptosis in vitro of murine thymocytes and of Th1 but not Th2 cells, suggesting that the selective deletion of T lymphocytes may be a major mechanism whereby tryptophile metabolism affects immunity under physiopathologic conditions.
Journal ArticleDOI
Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells
Maria Teresa Pallotta,Ciriana Orabona,Claudia Volpi,Carmine Vacca,Maria Laura Belladonna,Roberta Bianchi,Giuseppe Servillo,Cinzia Brunacci,Mario Calvitti,Silvio Bicciato,Emilia Maria Cristina Mazza,Louis Boon,Fabio Grassi,Maria C. Fioretti,Francesca Fallarino,Paolo Puccetti,Ursula Grohmann +16 more
TL;DR: It is found that IDO was involved in intracellular signaling events responsible for the self-amplification and maintenance of a stably regulatory phenotype in pDCs and has a tonic, nonenzymic function that contributes to TGF-β-driven tolerance in noninflammatory contexts.