Barbara C. McGrath

TL;DR: Evidence is provided that the short-term, combined effects of tryptophan deprivation and tryPTophan catabolites result in GCN2 kinase-dependent down-regulation of the TCR ζ-chain in murine CD8+ T cells.

TL;DR: A Perk knockout mutation is described in mice, which exhibits skeletal dysplasias at birth and postnatal growth retardation, and skeletal and pancreatic defects are associated with defects in the rough endoplasmic reticulum of the major secretory cells of the skeletal system and pancreas.

TL;DR: Reelin inhibits migration of cortical neurons and enables detachment of neurons from radial glia and may arrest neuronal migration and promote normal cortical lamination by binding alpha3beta1 integrin and modulating integrin-mediated cellular adhesion.

TL;DR: Overexpression of ATF3 in mouse embryo fibroblasts partially bypasses the requirement for PEK for induction of GADD34 in response to ER stress, further supporting the idea that ATF3 functions directly or indirectly as a transcriptional activator of genes targeted by the eIF2 kinase stress pathway.

TL;DR: It is shown that prenatal and neonatal mortalities are significantly increased in Gcn2 −/− mice whose mothers were reared on leucine-, tryptophan-, or glycine-deficient diets during gestation.