S
Sylvaine You
Researcher at University of Paris
Publications - 51
Citations - 3253
Sylvaine You is an academic researcher from University of Paris. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 22, co-authored 47 publications receiving 2921 citations. Previous affiliations of Sylvaine You include City of Hope National Medical Center & Paris Descartes University.
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Journal ArticleDOI
The Combined Effects of Tryptophan Starvation and Tryptophan Catabolites Down-Regulate T Cell Receptor ζ-Chain and Induce a Regulatory Phenotype in Naive T Cells
Francesca Fallarino,Ursula Grohmann,Sylvaine You,Barbara C. McGrath,Douglas R. Cavener,Carmine Vacca,Ciriana Orabona,Roberta Bianchi,Maria Laura Belladonna,Claudia Volpi,Pere Santamaria,Maria C. Fioretti,Paolo Puccetti +12 more
TL;DR: Evidence is provided that the short-term, combined effects of tryptophan deprivation and tryPTophan catabolites result in GCN2 kinase-dependent down-regulation of the TCR ζ-chain in murine CD8+ T cells.
Journal ArticleDOI
IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells
Yenkel Grinberg-Bleyer,Audrey Baeyens,Sylvaine You,Rima Elhage,Gwladys Fourcade,Sylvie Grégoire,Nicolas Cagnard,Wassila Carpentier,Qizhi Tang,Jeffrey A. Bluestone,Lucienne Chatenoud,David Klatzmann,Benoît L. Salomon,Eliane Piaggio +13 more
TL;DR: It is shown that 5 d of low-dose IL-2 administration starting at the time of T1D onset can reverse established disease in NOD (nonobese diabetic) mice, with long-lasting effects.
Journal ArticleDOI
Autoimmune Diabetes Onset Results From Qualitative Rather Than Quantitative Age-Dependent Changes in Pathogenic T-Cells
Sylvaine You,Mériam Belghith,Stephen P. Cobbold,Marie-Alexandra Alyanakian,Christine Gouarin,Samia Barriot,Corinne Garcia,Herman Waldmann,Jean-François Bach,Lucienne Chatenoud +9 more
TL;DR: It is demonstrated that 6-week-old pre-diabetic NOD mice, >2 months before disease onset, already harbor pathogenic T-cells in equal numbers to overtly diabetic animals, and it is proposed that progression to overt disease correlates with the pathogenicT-cell's escape from TGF-beta-dependent T-cell-mediated regulation.
Journal ArticleDOI
Adaptive TGF-β-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment
Sylvaine You,Bertrand Leforban,Corinne Garcia,Jean-François Bach,Jeffrey A. Bluestone,Lucienne Chatenoud +5 more
TL;DR: Results show that a subset of foxP3+ cells present within a CD4+CD25low lymphocyte subset suppresses T cell immunity in spontaneously diabetic NOD mice in a TGF-β-dependent manner, a functional property typical of “adaptive” regulatory T cells.
Journal ArticleDOI
Conventional and Neo-antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors
Gonzalez-Duque Sergio,Marie Eliane Azoury,Maikel Luis Colli,Georgia Afonso,Georgia Afonso,Georgia Afonso,Jean Valéry Turatsinze,Laura Nigi,Ana Inés Lalanne,Ana Inés Lalanne,Ana Inés Lalanne,Guido Sebastiani,Alexia Carré,Alexia Carré,Alexia Carré,Sheena Pinto,Slobodan Culina,Slobodan Culina,Slobodan Culina,Noémie Corcos,Noémie Corcos,Noémie Corcos,Marco Bugliani,Piero Marchetti,Mathieu Armanet,Marc Diedisheim,Bruno Kyewski,Lars M. Steinmetz,Søren Buus,Sylvaine You,Sylvaine You,Sylvaine You,Danièle Dubois-Laforgue,Etienne Larger,Jean Paul Beressi,Graziella Bruno,Francesco Dotta,Raphael Scharfmann,Raphael Scharfmann,Raphael Scharfmann,Decio L. Eizirik,Yann Verdier,Joëlle Vinh,Roberto Mallone +43 more
TL;DR: This peptidome opens new avenues to understand antigen processing by β cells and for the development of T cell biomarkers and tolerogenic vaccination strategies.