抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

I have developed "tennis elbow" from lugging this book around the past four weeks, but it is worth the pain, the effort, and the aspirin. It is also worth the (relatively speaking) bargain price. Including appendixes, this book contains 894 pages of text. The entire panorama of the neural sciences is surveyed and examined, and it is comprehensive in its scope, from genomes to social behaviors. The editors explicitly state that the book is designed as "an introductory text for students of biology, behavior, and medicine," but it is hard to imagine any audience, interested in any fragment of neuroscience at any level of sophistication, that would not enjoy this book. The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or

Principles of Neural Science

https://www.tau.ac.il/%7Eklafter1/258.pdf

The random walk's guide to anomalous diffusion: a fractional dynamics approach

We will review some of the major results in random graphs and some of the more challenging open problems. We will cover algorithmic and structural questions. We will touch on newer models, including those related to the WWW.

Random graphs

Statistics for Spatial Data.

A model of type III solar radio bursts is developed that incorporates large-angle scattering and reabsorption of fundamental emission amid ambient density fluctuations in the corona and solar wind Comparison with observations shows that this model accounts semiquantitatively for anomalous harmonic ratios, the exponential decay constant of bursts, burst rise times, and the directivity of fundamental emission It is concluded that the long emission tail on interplanetary type III bursts is mostly fundamental emission, while much of the anomalous time delay of fundamental relative to harmonic emission from a given location must be ascribed to other causes

Fundamental and Harmonic Emission in Type III Solar Radio Bursts – I. Emission at a Single Location or Frequency

A model is developed for the clumpy Langmuir waves observed in type III source regions. In this model the waves are generated by instability of a beam which propagates outward from the Sun in a state close to marginal stability. Ambient density perturbations cause fluctuations about the marginally stable state, leading to nonuniformities in both beam and waves and, hence, to spatially inhomogeneous growth. High damping rates and high wave levels are strongly anti-correlated, leading to suppression of the net damping. Below saturation stochastic growth causes the waves to follow a random walk in the logarithm of their energy density and the resulting probability of observing a field of magnitude E is approximately proportional to E-1. Comparison with observations shows that this model can account for the levels and clumpiness of the Langmuir waves, the small net dissipation required for the beams to propagate to 1 AU, the characteristic decay time of type III electromagnetic emission, and the negative mean growth rate observed in situ in type III sources. At 1 AU only the very highest fields approach the threshold for nonlinear wave collapse, but this threshold may be more commonly exceeded closer to the Sun.

Clumpy Langmuir waves in type III radio sources

Estimation of neurophysiological parameters from the waking EEG using a biophysical model of brain dynamics

The evolution of Langmuir and ion-sound waves in type 3 sources is investigated, incorporating linear growth, linear damping, and nonlinear electrostatic decay. Improved estimates are obtained for the wavenumber range of growing waves and the nonlinear coupling coefficient for the decay process. The resulting prediction for the electrostatic decay threshold is consistent with the observed high-field cutoff in the Langmuir field distribution. It is shown that the conditions in the solar wind do not allow a steady state to be attained; rather, bursty linear and nonlinear interactions take place, consistent with the highly inhomogeneous and impulsive waves actually observed. Nonlinear growth is found to be fast enough to saturate the growth of the parent Langmuir waves in the available interaction time. The resulting levels of product Langmuir and ion-sound waves are estimated theoretically and shown to be consistent with in situ ISEE 3 observations of type 3 events at 1 AU. Nonlinear interactions slave the growth and decay of product sound waves to that of the product Langmuir waves. The resulting probability distribution of ion-sound field strengths is predicted to have a flat tail extending to a high-field cutoff. This prediction is consistent with statistics derived here from ISEE 3 observations. Agreement is also found between the frequencies of the observed waves and predictions for the product S waves. The competing processes of nonlinear wave collapse and quasilinear relaxation are discussed, and it is concluded that neither is responsible for the saturation of Langmuir growth. When wave and beam inhomogeneities are accounted for, arguments from quasi-linear relaxation yield an upper bound on the Langmuir fields that is too high to be relevant. Nor are the criteria for direct wave collapse of the beam-driven waves met, consistent with earlier simulation results that imply that this process is not responsible for saturation of the beam instability. Indeed, even if the highest observed Langmuir fields are assumed to he part of a long-wavelength 'condensate' produced via electrostatic decay, they still fall short of the relevant requirements for wave collapse. The most stringent requirement for collapse is that collapsing wave packets not be disrupted by ambient density fluctuations in the solar wind. Fields of several mV m(exp -1) extending over several hundred km would be needed to satisfy this requirement; at 1 AU such fields are rare at best.

Peter A. Robinson

Papers

Fundamental and Harmonic Emission in Type III Solar Radio Bursts – I. Emission at a Single Location or Frequency

Clumpy Langmuir waves in type III radio sources

Estimation of neurophysiological parameters from the waking EEG using a biophysical model of brain dynamics

Dynamics of Langmuir and Ion-Sound Waves in Type III Solar Radio Sources

Neurophysical modeling of brain dynamics.