P
Peter B. Stranges
Researcher at University of Chicago
Publications - 2
Citations - 2114
Peter B. Stranges is an academic researcher from University of Chicago. The author has contributed to research in topics: Innate immune system & Antigen. The author has an hindex of 2, co-authored 2 publications receiving 1952 citations.
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Journal ArticleDOI
Innate immunity and intestinal microbiota in the development of Type 1 diabetes
Li Wen,Ruth E. Ley,Ruth E. Ley,Pavel Volchkov,Peter B. Stranges,Lia Avanesyan,Austin C. Stonebraker,Changyun Hu,F. Susan Wong,Gregory L. Szot,Jeffrey A. Bluestone,Jeffrey I. Gordon,Alexander V. Chervonsky +12 more
TL;DR: It is found that MyD88 deficiency changes the composition of the distal gut microbiota, and that exposure to the microbiota of specific pathogen-free MyD 88-negative NOD donors attenuates T1D in germ-free NOD recipients.
Journal ArticleDOI
Elimination of Antigen-Presenting Cells and Autoreactive T Cells by Fas Contributes to Prevention of Autoimmunity
Peter B. Stranges,Jessica Watson,Cristie J. Cooper,Caroline Morgane Choisy-Rossi,Austin C. Stonebraker,Ryan A. Beighton,Heather Hartig,John P. Sundberg,Stein Servick,Gunnar F. Kaufmann,Pamela J. Fink,Alexander V. Chervonsky +11 more
TL;DR: Analysis of mice with Fas loss restricted to T cells revealed that Fas indeed controls autoimmune T cells, but not T cells responding to strong antigenic stimulation, and Fas-dependent elimination of APCs is a major regulatory mechanism curbing autoimmune responses and acts in concert with Fas-mediated regulation of chronically activated autoimmune T Cells.