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Peter J. Alaimo
Researcher at Seattle University
Publications - 24
Citations - 1600
Peter J. Alaimo is an academic researcher from Seattle University. The author has contributed to research in topics: Chemical biology & Chemical genetics. The author has an hindex of 16, co-authored 24 publications receiving 1460 citations. Previous affiliations of Peter J. Alaimo include Lawrence Berkeley National Laboratory & University of California, San Francisco.
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Journal ArticleDOI
Useful Products from Complex Starting Materials: Common Chemicals from Biomass Feedstocks
TL;DR: Examination of the list of top production organic chemicals reveals numerous opportunities for future development, including simple halocarbons, alkenes and arenes, and future success is likely to continue through academic and industrial collaboration.
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Direct Photolysis of Human Metabolites of the Antibiotic Sulfamethoxazole: Evidence for Abiotic Back-Transformation
Florence Bonvin,Julien Omlin,Rebecca Rutler,W. Bernd Schweizer,Peter J. Alaimo,Timothy J. Strathmann,Kristopher McNeill,Tamar Kohn +7 more
TL;DR: Interestingly, photolytic back-transformation to SMX was observed for 4-nitroso-SMX, indicating that this metabolite may serve as an environmental source of SMX, underlines the importance of including human metabolites when assessing the effects of pharmaceuticals in the environment.
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Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain.
Huimin Wang,Eiji Shimizu,Ya-Ping Tang,Min Cho,Maureen Kyin,Wenqi Zuo,Daphné A. Robinson,Peter J. Alaimo,Chao Zhang,Hiromi Morimoto,Min Zhuo,Ruiben Feng,Ruiben Feng,Kevan M. Shokat,Joe Z. Tsien +14 more
TL;DR: The first postlearning week is revealed as the critical time window during which a precise level of CaMKII reactivation is essential for the consolidation of long-term memories in the brain.
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Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold.
Zachary A. Knight,Gary G. Chiang,Peter J. Alaimo,Denise M. Kenski,Caroline B. Ho,Kristin E. D. Coan,Robert T. Abraham,Kevan M. Shokat,Kevan M. Shokat +8 more
TL;DR: This work identifies multiplex inhibitors that potently inhibit distinct subsets of PI3-K isoforms, including the first selective inhibitor of p110beta/p110delta, thereby guiding future drug design based on this pharmacophore.
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Chemical genetic approaches for the elucidation of signaling pathways
TL;DR: In this paper, the advantages of genetics and chemistry to optimize the potency and specificity of small-molecule inhibitors are combined to study protein function in vivo and have provided insights into complex signaling cascades.