L
Leslie F. Lock
Researcher at University of California, Irvine
Publications - 21
Citations - 1963
Leslie F. Lock is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Stem cell & Gene. The author has an hindex of 15, co-authored 21 publications receiving 1879 citations. Previous affiliations of Leslie F. Lock include Johns Hopkins University School of Medicine & National Institutes of Health.
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Journal ArticleDOI
Requirement for mast cell growth factor for primordial germ cell survival in culture
Susanna Dolci,Douglas E. Williams,Mary K. Ernst,James L. Resnick,Camilynn I. Brannan,Leslie F. Lock,Stewart D. Lyman,Boswell Hs,Peter J. Donovan +8 more
TL;DR: It is reported that MGF is essential for PGC survival in culture, but does not stimulate PGC proliferation, thus explaining the sterility in mice carrying the steel-dickie (Sld) mutation.
Journal ArticleDOI
Induced Pluripotent Stem Cells from Patients with Huntington’s Disease : Show CAG Repeat-Expansion-Associated Phenotypes
Virginia B. Mattis,Soshana P. Svendsen,Allison D. Ebert,Clive N. Svendsen,Alvin R. King,Malcolm Casale,Sara T. Winokur,Gayani Batugedara,Marquis P. Vawter,Peter J. Donovan,Leslie F. Lock,Leslie M. Thompson,Yu Zhu,Elisa Fossale,Ranjit Singh Atwal,Tammy Gillis,Jayalakshmi S. Mysore,Jian Hong Li,Ihn Sik Seong,Yiping Shen,Xiaoli Chen,Vanessa C. Wheeler,Marcy E. MacDonald,James F. Gusella,Sergey S Akimov,Nicolas Arbez,Tarja A. Juopperi,Tamara Ratovitski,Jason H. Chiang,Woon Roung Kim,Eka Chighladze,Erin Watkin,Chun Zhong,Georgia Makri,Robert N. Cole,Russell L. Margolis,Hongjun Song,Guo Li Ming,Christopher A. Ross,Julia A. Kaye,Julia A. Kaye,Aaron C. Daub,Aaron C. Daub,Punita Sharma,Punita Sharma,Amanda R. Mason,Amanda R. Mason,Steven Finkbeiner,Steven Finkbeiner,Junying Yu,James A. Thomson,David Rushton,Stephen P. Brazier,Alysia Battersby,Amanda Redfern,Hsui Er Tseng,Alexander William John Harrison,Paul J. Kemp,Nicholas D. Allen,Marco Onorati,Valentina Castiglioni,Elena Cattaneo,Jamshid Arjomand +62 more
TL;DR: The generation and characterization of 14 induced pluripotent stem cell (iPSC) lines from HD patients and controls reveal CAG-repeat-expansion-associated gene expression patterns that distinguish patient lines from controls, and early onset versus late onset HD.
Journal ArticleDOI
Neurotrophins mediate human embryonic stem cell survival
TL;DR: It is demonstrated that hES cells express receptors of the tropomyosin-related kinase (TRK) family, which mediate antiapoptotic signals that improve hES cell survival and may facilitate their manipulation and the development of high-throughput screens to identify factors responsible for hes cell differentiation.
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Specific Loss of Histone H3 Lysine 9 Trimethylation and HP1γ/Cohesin Binding at D4Z4 Repeats Is Associated with Facioscapulohumeral Dystrophy (FSHD)
Weihua Zeng,Jessica C. de Greef,Yen Yun Chen,Richard Chien,Xiangduo Kong,Heather C. Gregson,Sara T. Winokur,April D. Pyle,Keith D. Robertson,John A. Schmiesing,Virginia Kimonis,Judit Balog,Rune R. Frants,Alexander R. Ball,Leslie F. Lock,Peter J. Donovan,Silvère M. van der Maarel,Kyoko Yokomori +17 more
TL;DR: A new model is proposed in which the epigenetic change initiated at 4q D4Z4 spreads its effect to other genomic regions, which compromises muscle-specific gene regulation leading to FSHD pathogenesis.
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Chromosomal localization of seven members of the murine TGF-β superfamily suggests close linkage to several morphogenetic mutant loci
Mary E. Dickinson,Michael S. Kobrin,Colleen M. Silan,David M. Kingsley,Monica J. Justice,Duncan A. Miller,Jeffrey D. Ceci,Leslie F. Lock,Angela Lee,Arthur M. Buchberg,Linda D. Siracusa,Karen M. Lyons,Rik Derynck,Brigid L.M. Hogan,Neal G. Copeland,Nancy A. Jenkins +15 more
TL;DR: Five of the eight loci of the TGF-beta superfamily mapped near mutant loci associated with connective tissue and skeletal disorders, raising the possibility that at least some of these mutations result from defects in T GF-beta-related genes.