P
Peter J. O'Brien
Researcher at University College Dublin
Publications - 318
Citations - 19961
Peter J. O'Brien is an academic researcher from University College Dublin. The author has contributed to research in topics: Glutathione & Cytotoxicity. The author has an hindex of 68, co-authored 316 publications receiving 18731 citations. Previous affiliations of Peter J. O'Brien include The Hertz Corporation & University of Toronto.
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Journal ArticleDOI
Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia
Junichi Fujii,Kinya Otsu,Francesco Zorzato,S de Leon,Vijay K. Khanna,J. E. Weiler,Peter J. O'Brien,David H. MacLennan +7 more
TL;DR: Haplotyping suggests that the mutation in all five breeds of lean, heavily muscled swine has a common origin, and the development of a noninvasive diagnostic test will provide the basis for elimination of the MH gene or its controlled inclusion in swine breeding programs.
Journal ArticleDOI
Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties.
Giuseppe Galati,Peter J. O'Brien +1 more
TL;DR: The current knowledge regarding potential dietary flavonoid/phenolic-induced toxicity concerns, including their pro-oxidant activity, mitochondrial toxicity (potential apoptosis-inducing properties), and interactions with drug-metabolizing enzymes are summarized.
Journal ArticleDOI
Molecular mechanisms of quinone cytotoxicity.
TL;DR: The higher redox potential benzoquinones and naphthoquinones are the most cytotoxic presumably because of their higher electrophilicty and thiol reactivity and/or because the quinones or GSH conjugates are more readily reduced to semiquinones which activate oxygen.
Journal ArticleDOI
Aldehyde sources, metabolism, molecular toxicity mechanisms, and possible effects on human health.
TL;DR: The human health risks from clinical and animal research studies are reviewed, including aldehydes as haptens in allergenic hypersensitivity diseases, respiratory allergies, and idiosyncratic drug toxicity; the potential carcinogenic risks of the carbonyl body burden.
Journal ArticleDOI
High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening.
Peter J. O'Brien,William Irwin,Dolores Diaz,E. Howard-Cofield,C. M. Krejsa,M. R. Slaughter,B. Gao,Nina Kaludercic,A. Angeline,Paolo Bernardi,P. Brain,C. Hougham +11 more
TL;DR: It is concluded that human hepatotoxicity is highly concordant with in vitro cytotoxicity in this novel model and as detected by HCS.