Journal ArticleDOI
Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties.
Giuseppe Galati,Peter J. O'Brien +1 more
TLDR
The current knowledge regarding potential dietary flavonoid/phenolic-induced toxicity concerns, including their pro-oxidant activity, mitochondrial toxicity (potential apoptosis-inducing properties), and interactions with drug-metabolizing enzymes are summarized.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2004-08-01. It has received 1001 citations till now. The article focuses on the topics: Isoflavones & Population.read more
Citations
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Biological effects of essential oils - A review
TL;DR: Findings suggest that, at least in part, the encountered beneficial effects of essential oils are due to prooxidant effects on the cellular level.
Journal ArticleDOI
Free radicals, metals and antioxidants in oxidative stress-induced cancer
TL;DR: This review examines the evidence for involvement of the oxidative stress in the carcinogenesis process and the role of enzymatic and non-enzymatic antioxidants in the process of carcinogenesis as well as the antioxidant interactions with various regulatory factors.
Journal ArticleDOI
Reconciling the chemistry and biology of reactive oxygen species
TL;DR: This review examines how target selectivity and antioxidant effectiveness vary for different oxidants and highlights areas where greater understanding is required on the fate of oxidants generated by cellular NADPH oxidases and on the identification of oxidant sensors in cell signaling.
Journal ArticleDOI
A review on antioxidants, prooxidants and related controversy: natural and synthetic compounds, screening and analysis methodologies and future perspectives.
TL;DR: The present review tries to shed some light on research on antioxidants (natural and synthetic) and prooxidants, showing the potential benefits and adverse effects of these opposing events, as well as their mechanisms of action and detection methodologies.
Journal ArticleDOI
Exogenous antioxidants--Double-edged swords in cellular redox state: Health beneficial effects at physiologic doses versus deleterious effects at high doses.
Jaouad Bouayed,Torsten Bohn +1 more
TL;DR: The double-edged effects of dietary originating antioxidants with a focus on the most abundant compounds, especially polyphenols, vitamin C, vitamin E and carotenoids are examined, highlighting that antioxidants at physiological doses are generally safe, exhibiting interesting health beneficial effects.
References
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Journal ArticleDOI
Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
Susan P.C. Cole,Gabu Bhardwaj,James H. Gerlach,J. E. Mackie,Caroline E. Grant,Kurt C. Almquist,Alistair J. Stewart,Ebba U. Kurz,A. M. V. Duncan,Roger G. Deeley +9 more
TL;DR: Reversion to drug sensitivity was associated with loss of gene amplification and a marked decrease in mRNA expression, and the mRNA encodes a member of the ATP-binding cassette transmembrane transporter superfamily.
Journal ArticleDOI
The mitochondrial permeability transition pore and its role in cell death.
TL;DR: Current evidence that the pore complex is involved in outer-membrane rupture and release of these proteins during programmed cell death is reviewed, along with indications that transient pore opening may provoke 'accidental' apoptosis.
Book
The Flavonoids: Advances in Research since 1980
TL;DR: In this paper, the authors discuss the distribution and evolution of the Flavonoids in the Lower Plants and its evolution in the Dicotyledons of the world's plants.
Journal ArticleDOI
Flavonoids: antioxidants or signalling molecules?
TL;DR: A clear understanding of the mechanisms of action of flavonoids, either as antioxidants or modulators of cell signalling, and the influence of their metabolism on these properties are key to the evaluation of these potent biomolecules as anticancer agents, cardioprotectants, and inhibitors of neurodegeneration.
Journal ArticleDOI
Tannins and Human Health: A Review
TL;DR: The aim of this review is to summarize and analyze the vast and sometimes conflicting literature on tannins and to provide as accurately as possible the needed information for assessment of the overall effects of tannin effects on human health.