P
Peter J. Schüffler
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 64
Citations - 2781
Peter J. Schüffler is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Digital pathology & Medicine. The author has an hindex of 21, co-authored 54 publications receiving 2069 citations. Previous affiliations of Peter J. Schüffler include University of Zurich & Technische Universität München.
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Journal ArticleDOI
Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry
Charlotte Giesen,Hao A. O. Wang,Denis Schapiro,Nevena Zivanovic,Andrea Jacobs,Bodo Hattendorf,Peter J. Schüffler,Daniel Grolimund,Joachim M. Buhmann,Simone Brandt,Zsuzsanna Varga,Peter J. Wild,Detlef Günther,Bernd Bodenmiller +13 more
TL;DR: The coupled immunohistochemical and immunocytochemical methods with high-resolution laser ablation to CyTOF mass cytometry enables the simultaneous imaging of 32 proteins and protein modifications at subcellular resolution and complements existing imaging approaches.
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Cancer genetics-guided discovery of serum biomarker signatures for diagnosis and prognosis of prostate cancer
Igor Cima,Ralph Schiess,Peter J. Wild,Martin Kaelin,Peter J. Schüffler,Vinzenz Lange,Paola Picotti,Reto Ossola,Arnoud J. Templeton,Olga T. Schubert,Thomas J. Fuchs,Thomas Leippold,Stephen Wyler,Jens Zehetner,Wolfram Jochum,Joachim M. Buhmann,Thomas Cerny,Holger Moch,Silke Gillessen,Ruedi Aebersold,Ruedi Aebersold,Wilhelm Krek +21 more
TL;DR: A two-stage strategy for the discovery of serum biomarker signatures corresponding to specific cancer-causing mutations and its application to prostate cancer (PCa) in the context of the commonly occurring phosphatase and tensin homolog (PTEN) tumor-suppressor gene inactivation.
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Whole slide imaging equivalency and efficiency study: experience at a large academic center.
Matthew G. Hanna,Victor E. Reuter,Meera Hameed,Lee K. Tan,Sarah Chiang,Carlie S. Sigel,Travis J. Hollmann,Dilip Giri,Jennifer Samboy,Carlos Moradel,Andrea Rosado,John R. Otilano,Christine England,Lorraine Corsale,Evangelos Stamelos,Yukako Yagi,Peter J. Schüffler,Thomas J. Fuchs,David S. Klimstra,S. Joseph Sirintrapun +19 more
TL;DR: This randomized, equivalency and efficiency study aimed to replicate clinical workflow, comparing conventional microscopy to a complete digital pathology signout using whole slide images, evaluating the equivalencies and efficiency of glass slide to whole slide image reporting, reflective of true pathology practice workloads in the clinical setting.
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Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer
Jürgen Veeck,Peter J. Wild,Thomas J. Fuchs,Peter J. Schüffler,Arndt Hartmann,Ruth Knüchel,Edgar Dahl +6 more
TL;DR: Although the Wnt antagonist genes WIF1 and DKK3 show a very similar frequency of promoter methylation in human breast cancer, only DKK 3 methylation proves as a novel prognostic marker potentially useful in the clinical management of this disease.
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Validation of a digital pathology system including remote review during the COVID-19 pandemic.
Matthew G. Hanna,Victor E. Reuter,Orly Ardon,David H. Kim,Sahussapont Joseph Sirintrapun,Peter J. Schüffler,Klaus J. Busam,Jennifer L. Sauter,Edi Brogi,Lee K. Tan,Bin Xu,Tejus Bale,Narasimhan P. Agaram,Laura H. Tang,Lora H. Ellenson,John Philip,Lorraine Corsale,Evangelos Stamelos,Maria A. Friedlander,Peter Ntiamoah,Marc Labasin,Christine England,David S. Klimstra,Meera Hameed +23 more
TL;DR: This randomized, prospective study successfully validated remote use of a digital pathology system including operational feasibility supporting remote review and reporting of pathology specimens, and evaluation of remote access performance and usability for remote signout.