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TOPICAL REVIEW: Applications of magnetic nanoparticles in biomedicine

The physical principles underlying some current biomedical applications of magnetic nanoparticles are reviewed. Starting from well-known basic concepts, and drawing on examples from biology and biomedicine, the relevant physics of magnetic materials and their responses to applied magnetic fields are surveyed. The way these properties are controlled and used is illustrated with reference to (i) magnetic separation of labelled cells and other biological entities; (ii) therapeutic drug, gene and radionuclide delivery; (iii) radio frequency methods for the catabolism of tumours via hyperthermia; and (iv) contrast enhancement agents for magnetic resonance imaging applications. Future prospects are also discussed.

https://iopscience.iop.org/article/10.1088/0022-3727/36/13/201/pdf

Applications of magnetic nanoparticles in biomedicine

Biocompatibility, Pharmaceutical and Biomedical Applications L. Harivardhan Reddy,†,‡ Jose ́ L. Arias, Julien Nicolas,† and Patrick Couvreur*,† †Laboratoire de Physico-Chimie, Pharmacotechnie et Biopharmacie, Universite ́ Paris-Sud XI, UMR CNRS 8612, Faculte ́ de Pharmacie, IFR 141, 5 rue Jean-Baptiste Cleḿent, F-92296 Chat̂enay-Malabry, France Departamento de Farmacia y Tecnología Farmaceútica, Facultad de Farmacia, Campus Universitario de Cartuja s/n, Universidad de Granada, 18071 Granada, Spain ‡Pharmaceutical Sciences Department, Sanofi, 13 Quai Jules Guesdes, F-94403 Vitry-sur-Seine, France

Magnetic nanoparticles: design and characterization, toxicity and biocompatibility, pharmaceutical and biomedical applications.

http://pharmaquest.weebly.com/uploads/9/9/4/2/9942916/superparamagnetic_iron_oxide_nanoparticles_spions.pdf

Superparamagnetic iron oxide nanoparticles (SPIONs): Development, surface modification and applications in chemotherapy

A magnetic field induced agglomeration of magnetic and µm-sized copper non-magnetic particles in magnetic fluid with several volume concentrations of magnetite and copper particles was studied by means of optical microscope equipped with video camera. Transmission of light through two crossed polarizers and thin magnetic fluid and magnetic fluid composites film as a function of magnetic field was investigated. The experimental data showed that the presence of copper particles influences the aggregation processes of magnetic particles in magnetic fluids and transmissivity of light.

The structuralization phenomena in magnetic fluid composites and their influence on transmissivity of light

Phase transitions of different binary mixtures of a bent-core (10DClPBBC) and a rod-shaped (6OO8) liquid crystal were studied using differential scanning calorimetry. For the binary mixture with 50:50 weight ratio of bent-core and rod-shaped molecules, the nematic to smectic transition occurred below the temperature of 40°C and crystallization was shifted to sub-ambient temperature. It was found that crystallization was the phase transition with the lowest apparent activation energy.

DSC Study of Bent-Core and Rod-Shaped Liquid Crystal Mixtures

Acoustic spectroscopy of functionalized carbon nanotubes in magnetic fluid

Effect of structural site disorder on the optical properties of Ag6+x(P1−xGex)S5I solid solutions

Structural changes in the nematic liquid crystal 6CHBT doped with a low concentration (1×10−4, 5×10−4) of magnetic nanorods induced by weak magnetic field in the increasing/decreasing mode, as well as in pulsed regime are investigated using surface acoustic waves and magneto-optical effect. The responses of both surface acoustic waves attenuation and optical transmission of the linearly polarized laser beam (532 nm) passing through the sample were investigated. The role of the concentration of magnetic nanorods on structural changes and corresponding magneto-optical behavior concerning the system stability and switching time under applied field was determined. The obtained results of both methods confirmed an effective orientational coupling between particles’ magnetic moments and liquid crystal molecules and showed the effectivity of measurements relying on suspension stability and switching processes.

/pdf/effect-of-magnetic-particles-on-structural-changes-and-jplzqdxv21.pdf

Peter Kopčanský

Papers

The structuralization phenomena in magnetic fluid composites and their influence on transmissivity of light

DSC Study of Bent-Core and Rod-Shaped Liquid Crystal Mixtures

Acoustic spectroscopy of functionalized carbon nanotubes in magnetic fluid

Effect of structural site disorder on the optical properties of Ag6+x(P1−xGex)S5I solid solutions

Effect of Magnetic Particles on Structural Changes and Magneto-Optical Behavior of Liquid Crystal