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Peter-Martin Bruch
Researcher at Heidelberg University
Publications - 8
Citations - 109
Peter-Martin Bruch is an academic researcher from Heidelberg University. The author has contributed to research in topics: Chronic lymphocytic leukemia & Somatic evolution in cancer. The author has an hindex of 2, co-authored 8 publications receiving 34 citations. Previous affiliations of Peter-Martin Bruch include University Hospital Heidelberg & Molecular Medicine Partnership Unit.
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Journal ArticleDOI
Dissecting intratumour heterogeneity of nodal B-cell lymphomas at the transcriptional, genetic and drug-response levels
Tobias Roider,Tobias Roider,Tobias Roider,Julian Seufert,Julian Seufert,Alexey Uvarovskii,Felix Frauhammer,Marie Bordas,Nima Abedpour,Marta Stolarczyk,Jan-Philipp Mallm,Sophie A. Herbst,Peter-Martin Bruch,Peter-Martin Bruch,Peter-Martin Bruch,Hyatt Balke-Want,Michael Hundemer,Karsten Rippe,Benjamin Goeppert,Martina Seiffert,Benedikt Brors,Gunhild Mechtersheimer,Thorsten Zenz,Martin Pfeifer,Björn Chapuy,Matthias Schlesner,Carsten Müller-Tidow,Carsten Müller-Tidow,Carsten Müller-Tidow,Stefan Fröhling,Wolfgang Huber,Wolfgang Huber,Simon Anders,Sascha Dietrich +33 more
TL;DR: The heterogeneity of nodal B-cell lymphomas is studied by single-cell RNA-sequencing and transcriptome-informed flow cytometry and the relevance of intratumour heterogeneity for personalized cancer therapy is highlighted.
Journal ArticleDOI
Multi-omics reveals clinically relevant proliferative drive associated with mTOR-MYC-OXPHOS activity in chronic lymphocytic leukemia
Junyan Lu,Junyan Lu,Ester Cannizzaro,Fabienne Meier-Abt,Sebastian Scheinost,Peter-Martin Bruch,Peter-Martin Bruch,Peter-Martin Bruch,Holly A. R. Giles,Holly A. R. Giles,Almut Lütge,Jennifer Hüllein,Jennifer Hüllein,Lena Wagner,Brian Giacopelli,Ferran Nadeu,Julio Delgado,Elias Campo,Maurizio Mangolini,Ingo Ringshausen,Martin Böttcher,Dimitrios Mougiakakos,Andrea Jacobs,Bernd Bodenmiller,Sascha Dietrich,Christopher C. Oakes,Thorsten Zenz,Thorsten Zenz,Wolfgang Huber,Wolfgang Huber +29 more
TL;DR: In this paper, the authors devised a method for simultaneous subgroup discovery across multiple data types and applied it to genomic, transcriptomic, DNA methylation and ex-vivo drug response data from 217 chronic Lymphocytic Leukemia (CLL) cases.
Journal ArticleDOI
Systematic Investigation of Microenvironmental Drug Resistance Mechanisms in Chronic Lymphocytic Leukemia
Peter-Martin Bruch,Peter-Martin Bruch,Peter-Martin Bruch,Holly A. R. Giles,Holly A. R. Giles,Carolin Kolb,Sophie Rabe,Tobias Roider,Tobias Roider,Tobias Roider,Mareike Knoll,Mark Kriegsmann,Katharina Kriegsmann,Christiane Zgorzelski,Sebastian Scheinost,Lena Wagner,Carsten Müller-Tidow,Carsten Müller-Tidow,Thorsten Zenz,Wolfgang Huber,Wolfgang Huber,Sascha Dietrich +21 more
TL;DR: A high-throughput perturbation assay combining pairwise 15 clinically relevant drugs with 18 stimulations mimicking the tumor microenvironment found the strongest pro-survival effects were mediated by IL-4 and Toll-like receptor (TLR) 7/8/9 stimulation, whereas transforming growth factor β1 and Interleukin-6 reduced the viability of CLL cells in-vitro.
Journal ArticleDOI
Longitudinal analyses of CLL in mice identify leukemia-related clonal changes including a Myc gain predicting poor outcome in patients.
Selcen Öztürk,Yashna Paul,Saira Afzal,Irene Gil-Farina,Anna Jauch,Peter-Martin Bruch,Verena Kalter,Bola S. Hanna,Lavinia Arseni,Philipp M. Roessner,Manfred Schmidt,Stephan Stilgenbauer,Sascha Dietrich,Peter Lichter,Marc Zapatka,Martina Seiffert +15 more
TL;DR: In this paper, the authors performed whole exome and B-cell receptor sequencing of longitudinal leukemia samples of Eµ-TCL1 mice and found that leukemia in these mice is mostly monoclonal, indicating that TCL1 overexpression is not sufficient for full leukemic transformation.
Posted ContentDOI
Haplotype-aware single-cell multiomics uncovers functional effects of somatic structural variation
Hyobin Jeong,Karen Grimes,Peter-Martin Bruch,Peter-Martin Bruch,Tobias Rausch,Patrick Hasenfeld,Radhakrishnan Sabarinathan,David Porubsky,David Porubsky,Sophie A. Herbst,Sophie A. Herbst,Büşra Erarslan-Uysal,Johann-Christoph Jann,Tobias Marschall,Daniel Nowak,Jean-Pierre Bourquin,Andreas E. Kulozik,Andreas E. Kulozik,Sascha Dietrich,Sascha Dietrich,Sascha Dietrich,Beat Bornhauser,Ashley D. Sanders,Jan O. Korbel +23 more
TL;DR: In this article, a computational method, scNOVA, was proposed that couples SV discovery with nucleosome occupancy analysis by haplotype-resolved single-cell sequencing, to systematically uncover SV effects on cis-regulatory elements and gene activity.