J
Julio Delgado
Researcher at University of Barcelona
Publications - 296
Citations - 10739
Julio Delgado is an academic researcher from University of Barcelona. The author has contributed to research in topics: Chronic lymphocytic leukemia & IGHV@. The author has an hindex of 43, co-authored 263 publications receiving 8590 citations. Previous affiliations of Julio Delgado include The Royal Marsden NHS Foundation Trust & Hospital de Sant Pau.
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Journal ArticleDOI
Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia.
John C. Byrd,Jennifer R. Brown,Susan O'Brien,Jacqueline C. Barrientos,Neil E. Kay,Nishitha Reddy,Steven Coutre,Constantine S. Tam,Stephen P. Mulligan,Ulrich Jaeger,S Devereux,Paul M. Barr,Richard R. Furman,Thomas J. Kipps,Florence Cymbalista,Christopher Pocock,Patrick Thornton,Federico Caligaris-Cappio,Tadeusz Robak,Julio Delgado,Stephen J. Schuster,Marco Montillo,Anna Schuh,S. de Vos,Devinder Gill,Adrian Bloor,Claire Dearden,Carol Moreno,Jeffrey Jones,Alvina D. Chu,Maria Fardis,Jesse McGreivy,Fong Clow,Danelle F. James,Peter Hillmen +34 more
TL;DR: Ibrutinib, as compared with ofatumumab, significantly improved progression-free survival, overall survival, and response rate among patients with previously treated CLL or SLL.
Journal ArticleDOI
Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia.
Víctor Quesada,Laura Conde,Neus Villamor,Gonzalo R. Ordóñez,Pedro Jares,Laia Bassaganyas,Andrew J. Ramsay,Sílvia Beà,Magda Pinyol,Alejandra Martínez-Trillos,Mónica López-Guerra,Dolors Colomer,Alba Navarro,Tycho Baumann,Marta Aymerich,María Rozman,Julio Delgado,Eva Giné,Jesús M. Hernández,Marcos González-Díaz,Diana A. Puente,Gloria Velasco,José M.P. Freije,Jose M. C. Tubio,Romina Royo,Josep Lluís Gelpí,Modesto Orozco,David G. Pisano,Jorge Zamora,Miguel Vazquez,Alfonso Valencia,Heinz Himmelbauer,Mònica Bayés,Simon Heath,Marta Gut,Ivo Gut,Xavier Estivill,Armando López-Guillermo,Xose S. Puente,Elias Campo,Carlos López-Otín +40 more
TL;DR: This work provides the first comprehensive catalog of somatic mutations in CLL with relevant clinical correlates and defines a large set of new genes that may drive the development of this common form of leukemia.
Journal ArticleDOI
Non-coding recurrent mutations in chronic lymphocytic leukaemia
Xose S. Puente,Sílvia Beà,Rafael Valdés-Mas,Neus Villamor,Jesús Gutiérrez-Abril,José I. Martín-Subero,Marta Munar,Carlota Rubio-Perez,Pedro Jares,Marta Aymerich,Tycho Baumann,Renée Beekman,Laura Belver,Anna Carrió,Giancarlo Castellano,Guillem Clot,Enrique Colado,Dolors Colomer,Dolors Costa,Julio Delgado,Anna Enjuanes,Xavier Estivill,Adolfo A. Ferrando,Josep Lluís Gelpí,Blanca Gonzalez,Santiago Gonzalez,Marcos González,Marta Gut,Jesús M. Hernández-Rivas,Mónica López-Guerra,David Martín-García,Alba Navarro,Pilar Nicolás,Modesto Orozco,Angel Ramirez Payer,Magda Pinyol,David G. Pisano,Diana A. Puente,Ana C. Queirós,Víctor Quesada,Carlos M. Romeo-Casabona,Cristina Royo,Romina Royo,María Rozman,Nuria Russiñol,Itziar Salaverria,Kostas Stamatopoulos,Hendrik G. Stunnenberg,David Tamborero,María José Terol,Alfonso Valencia,Nuria Lopez-Bigas,David Torrents,Ivo Gut,Armando López-Guillermo,Carlos López-Otín,Elias Campo +56 more
TL;DR: An integrated portrait of the CLL genomic landscape is provided, new recurrent driver mutations of the disease are identified, and clinical interventions that may improve the management of this neoplasia are suggested.
Journal ArticleDOI
Acquired Haemophilia: Review and Meta‐Analysis Focused on Therapy and Prognostic Factors
Julio Delgado,Víctor Jiménez-Yuste,Fernando Hernandez-Navarro,Fernando Hernandez-Navarro,A. Villar +4 more
TL;DR: A succinct review of the clinical features, laboratory diagnosis, prognostic factors and therapeutic management of patients with acquired haemophilia is provided.
Journal ArticleDOI
Clinical impact of clonal and subclonal TP53, SF3B1, BIRC3, NOTCH1 and ATM mutations in chronic lymphocytic leukemia
Ferran Nadeu,Julio Delgado,Cristina Royo,Tycho Baumann,Tatjana Stankovic,Magda Pinyol,Pedro Jares,Alba Navarro,David Martín-García,Sílvia Beà,Itziar Salaverria,Ceri E. Oldreive,Marta Aymerich,Helena Suárez-Cisneros,María Rozman,Neus Villamor,Dolors Colomer,Armando López-Guillermo,Marcos González,Miguel Alcoceba,María José Terol,Enrique Colado,Xose S. Puente,Carlos López-Otín,Anna Enjuanes,Elias Campo +25 more
TL;DR: Clonal evolution in longitudinal samples mainly occurred in cases with mutations in the initial samples and was observed not only after chemotherapy but also in untreated patients, suggesting that the characterization of the subclonal architecture and its dynamics in the evolution of the disease may be relevant for the management of CLL patients.