P
Peter R. Flatt
Researcher at Ulster University
Publications - 692
Citations - 21500
Peter R. Flatt is an academic researcher from Ulster University. The author has contributed to research in topics: Insulin & Glucose homeostasis. The author has an hindex of 68, co-authored 667 publications receiving 19320 citations. Previous affiliations of Peter R. Flatt include Queen's University Belfast & Royal College of Surgeons in Ireland.
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Journal ArticleDOI
Glucagon-like peptide 1 (GLP-1)
Timo D. Müller,Brian Finan,Stephen R. Bloom,David A. D'Alessio,Daniel J. Drucker,Peter R. Flatt,Andreas Fritsche,Fiona M. Gribble,Harvey J. Grill,Joel F. Habener,Jens J. Holst,Wolfgang Langhans,Juris J. Meier,Michael A. Nauck,Diego Perez-Tilve,Alessandro Pocai,Frank Reimann,Darleen A. Sandoval,Thue W. Schwartz,Randy J. Seeley,Kerstin Stemmer,Mads Tang-Christensen,Stephen C. Woods,Richard D. DiMarchi,M.H. Tschöp +24 more
TL;DR: The numerous beneficial effects of GLP-1 render this hormone an interesting candidate for the development of pharmacotherapies to treat obesity, diabetes, and neurodegenerative disorders.
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Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice
TL;DR: It is suggested that certain traditional plant treatments for diabetes, namely agrimony, alfalfa, coriander, eucalyptus and juniper, can retard the development of streptozotocin diabetes in mice.
Journal ArticleDOI
Abnormal plasma glucose and insulin responses in heterozygous lean (ob/+) mice.
Peter R. Flatt,C. J. Bailey +1 more
TL;DR: An effect of the ob gene on glucose homeostasis in heterozygous lean (ob/+) mice is demonstrated, suggesting that ob/+ mice might prove useful to study factors predisposing to inappropriate hyperglycaemia.
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Characterization of a Novel Glucose-Responsive Insulin-Secreting Cell Line, BRIN-BD11, Produced by Electrofusion
Neville H. McClenaghan,Christopher R. Barnett,Eric Ah-Sing,Yasser Abdel-Wahab,Finbarr O'Harte,Tai-Wook Yoon,Sara K. Swanston-Flatt,Peter R. Flatt +7 more
TL;DR: High-performance liquid chromatography analysis demonstrated that insulin was the major product secreted under stimulatory conditions, and western blotting confirmed that BRIN-BD11 cells expressed the GLUT2 glucose transporter, confirming an intact glucose sensing mechanism.
Journal ArticleDOI
Insulin-releasing and insulin-like activity of the traditional anti-diabetic plant Coriandrum sativum (coriander).
Alison Gray,Peter R. Flatt +1 more
TL;DR: The presence of antihyperglycaemic, insulin-releasing and insulin-like activity in Coriandrum sativum is demonstrated and sequential extraction with solvents revealed insulin- releasing activity in hexane and water fractions indicating a possible cumulative effect of more than one extract constituent.