M
M.H. Tschöp
Researcher at University of Cincinnati
Publications - 10
Citations - 1650
M.H. Tschöp is an academic researcher from University of Cincinnati. The author has contributed to research in topics: Ghrelin & Agonist. The author has an hindex of 9, co-authored 10 publications receiving 1216 citations. Previous affiliations of M.H. Tschöp include Helmholtz Zentrum München & Technische Universität München.
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Journal ArticleDOI
Glucagon-like peptide 1 (GLP-1)
Timo D. Müller,Brian Finan,Stephen R. Bloom,David A. D'Alessio,Daniel J. Drucker,Peter R. Flatt,Andreas Fritsche,Fiona M. Gribble,Harvey J. Grill,Joel F. Habener,Jens J. Holst,Wolfgang Langhans,Juris J. Meier,Michael A. Nauck,Diego Perez-Tilve,Alessandro Pocai,Frank Reimann,Darleen A. Sandoval,Thue W. Schwartz,Randy J. Seeley,Kerstin Stemmer,Mads Tang-Christensen,Stephen C. Woods,Richard D. DiMarchi,M.H. Tschöp +24 more
TL;DR: The numerous beneficial effects of GLP-1 render this hormone an interesting candidate for the development of pharmacotherapies to treat obesity, diabetes, and neurodegenerative disorders.
Journal ArticleDOI
Physiology: does gut hormone PYY3-36 decrease food intake in rodents?
M.H. Tschöp,Tamara R. Castañeda,H. G. Joost,Christa Thöne-Reineke,Ortmann S,Susanne Klaus,Mary M. Hagan,Chandler Pc,Oswald Kd,Stephen C. Benoit,Randy J. Seeley,K. P. Kinzig,T. H. Moran,Beck-sickinger Ag,Koglin N,R.J. Rodgers,Blundell Je,Y. Ishii,A. H. Beattie,Patricia Holch,David B. Allison,Raun K,Madsen K,Wulff Bs,Stidsen Ce,Marc Birringer,O. J. Kreuzer,Schindler M,Arndt K,Rudolf K,M. Mark,Xiaolan Deng,Whitcomb Dc,Halem H,Taylor J,J. Dong,Datta R,M Culler,S. Craney,D. Flora,Smiley D,Heiman Ml +41 more
TL;DR: The fact that the findings of Batterham et al. cannot easily be replicated calls into question the potential value of an anti-obesity approach that is based on administration of PYY3–36.
Journal ArticleDOI
Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure
Paul T. Pfluger,Henriette Kirchner,Susanne Gunnel,Brigitte Schrott,Diego Perez-Tilve,Sheng Fu,Stephen C. Benoit,Tamas L. Horvath,Hans-Georg Joost,Katherine E. Wortley,Mark W. Sleeman,M.H. Tschöp +11 more
TL;DR: It is demonstrated that simultaneous deletion of Ghr and its receptor enhances the metabolic phenotype of single gene-deficient mice compared with WT mice, possibly suggesting the existence of additional, as of yet unknown, molecular components of the endogenous Ghr system.
Journal ArticleDOI
PYY3-36 as an anti-obesity drug target.
Mary M. Boggiano,P. C. Chandler,Kimberly D. Oswald,R.J. Rodgers,John E. Blundell,Y. Ishii,A. H. Beattie,Patricia Holch,David B. Allison,Marcus Schindler,Kirsten Arndt,Klaus Rudolf,M. Mark,C. Schoelch,H. G. Joost,Susanne Klaus,Christa Thöne-Reineke,Stephen C. Benoit,Randy J. Seeley,Annette G. Beck-Sickinger,Norman Koglin,Kirsten Raun,Kjeld Madsen,Birgitte Schjellerup Wulff,Carsten Enggaard Stidsen,Marc Birringer,Oliver J. Kreuzer,X. Y. Deng,D. C. Whitcomb,Heather A. Halem,John E. Taylor,Jesse Z. Dong,Rakesh Datta,Michael D. Culler,Sylvia Ortmann,Tamara R. Castañeda,M.H. Tschöp +36 more
TL;DR: Data speak against a sustained decrease in food intake, body fat, or body weight gain following PYY3‐36 administration and make the previously suggested role of the hypothalamic melanocortin system unlikely as is the existence of PYY deficiency in human obesity.
Journal ArticleDOI
CNS Leptin Action Modulates Immune Response and Survival in Sepsis
Johannes Tschöp,Rubén Nogueiras,Sarah Haas-Lockie,Sarah Haas-Lockie,Kevin R. Kasten,Tamara R. Castañeda,Nadine Huber,Kelsey Guanciale,Diego Perez-Tilve,Kirk M. Habegger,Nickki Ottaway,Stephen C. Woods,Brian J. Oldfield,Iain J. Clarke,Streamson C. Chua,I. S. Farooqi,Stephen O'Rahilly,Charles C. Caldwell,M.H. Tschöp +18 more
TL;DR: It is reported that leptin signaling in the brain increases survival during sepsis in leptin-deficient as well as in wild-type mice and that endogenous CNS leptin action is required for an adequate systemic immune response.