D
David Roberson
Researcher at Leidos
Publications - 35
Citations - 2529
David Roberson is an academic researcher from Leidos. The author has contributed to research in topics: Cancer & Sensory Receptor Cells. The author has an hindex of 22, co-authored 35 publications receiving 1984 citations. Previous affiliations of David Roberson include National Institutes of Health & United States Department of Health and Human Services.
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Journal ArticleDOI
Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation
Sébastien Talbot,Sébastien Talbot,Raja-Elie E. Abdulnour,Patrick R. Burkett,Seungkyu Lee,Seungkyu Lee,Shane J. F. Cronin,Shane J. F. Cronin,Maud Pascal,Maud Pascal,Maud Pascal,Cédric J. Laedermann,Cédric J. Laedermann,Simmie L. Foster,Simmie L. Foster,Johnathan V. Tran,Johnathan V. Tran,Nicole Y. Lai,Nicole Y. Lai,Isaac M. Chiu,Isaac M. Chiu,Nader Ghasemlou,Nader Ghasemlou,Matthew DiBiase,Matthew DiBiase,David Roberson,David Roberson,Christian A. von Hehn,Christian A. von Hehn,Busranour Agac,Busranour Agac,Oliver Haworth,Hiroyuki Seki,Josef M. Penninger,Vijay K. Kuchroo,Bruce P. Bean,Bruce D. Levy,Clifford J. Woolf,Clifford J. Woolf +38 more
TL;DR: It is discovered that IL-5, a cytokine produced by activated immune cells, acts directly on nociceptors to induce the release of vasoactive intestinal peptide (VIP), creating an inflammatory signaling loop that promotes allergic inflammation.
Journal ArticleDOI
Breaking barriers to novel analgesic drug development
TL;DR: Recent advances in the understanding of the neurobiology of pain are beginning to offer opportunities for developing novel therapeutic strategies and revisiting existing targets, including modulating ion channels, enzymes and G-protein-coupled receptors.
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Multi-platform assessment of transcriptome profiling using RNA-seq in the ABRF next-generation sequencing study
Sheng Li,Scott Tighe,Charles M Nicolet,Deborah S. Grove,Shawn Levy,William G. Farmerie,Agnes Viale,Chris L. Wright,Peter A. Schweitzer,Yuan Gao,Dewey Kim,Joe Boland,Belynda Hicks,Ryan W. Kim,Sagar Chhangawala,Nadereh Jafari,Nalini Raghavachari,Jorge Gandara,Natàlia Garcia-Reyero,Cynthia Hendrickson,David Roberson,Jeffrey A. Rosenfeld,Todd M. Smith,Jason G. Underwood,May D. Wang,Paul Zumbo,Don A. Baldwin,George Grills,Christopher E. Mason +28 more
TL;DR: This study provides a broad foundation for cross-platform standardization, evaluation and improvement of RNA-seq, showing high intraplatform and inter-platform concordance for expression measures across the deep-count platforms, but highly variable efficiency and cost for splice junction and variant detection between all platforms.
Journal ArticleDOI
Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity
Isaac M. Chiu,Lee Barrett,Erika K. Williams,David E. Strochlic,Seungkyu Lee,Andy D. Weyer,Shan Lou,Gregory S. Bryman,David Roberson,Nader Ghasemlou,Cara Piccoli,Ezgi Ahat,Victor Wang,Enrique J. Cobos,Cheryl L. Stucky,Qiufu Ma,Stephen D. Liberles,Clifford J. Woolf +17 more
TL;DR: Transcriptional profiling is used to analyze the detailed molecular signatures of dorsal root ganglion (DRG) sensory neurons and uncover potentially novel subsets, revealing the complexity and diversity of those neurons underlying somatosensation.
Journal ArticleDOI
HPV16 E7 Genetic Conservation Is Critical to Carcinogenesis
Lisa Mirabello,Meredith Yeager,Kai Yu,Gary M. Clifford,Yanzi Xiao,Bin Zhu,Michael Cullen,Michael Cullen,Joseph Boland,Joseph Boland,Nicolas Wentzensen,Chase W. Nelson,Tina Raine-Bennett,Zigui Chen,Sara Bass,Sara Bass,Lei Song,Lei Song,Qi Yang,Qi Yang,Mia Steinberg,Mia Steinberg,Laurie Burdett,Laurie Burdett,Michael Dean,David Roberson,David Roberson,Jason Mitchell,Jason Mitchell,Thomas Lorey,Silvia Franceschi,Philip E. Castle,Joan L. Walker,Rosemary E. Zuna,Aimée R. Kreimer,Daniel C. Beachler,Allan Hildesheim,Paula Gonzalez,Carolina Porras,Robert D. Burk,Mark Schiffman +40 more
TL;DR: Strict conservation of the 98 amino acids of E7, which disrupts Rb function, is critical for HPV16 carcinogenesis, presenting a highly specific target for etiologic and therapeutic research.