P
Petra Popovics
Researcher at University of Wisconsin-Madison
Publications - 34
Citations - 631
Petra Popovics is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Growth hormone–releasing hormone & Prostate. The author has an hindex of 13, co-authored 29 publications receiving 525 citations. Previous affiliations of Petra Popovics include University of St Andrews & Dresden University of Technology.
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Journal ArticleDOI
GPR39: a Zn(2+)-activated G protein-coupled receptor that regulates pancreatic, gastrointestinal and neuronal functions.
Petra Popovics,Alan J. Stewart +1 more
TL;DR: GPR39 is now emerging as an important transducer of autocrine and paracrine Zn2+ signals, impacting upon cellular processes such as insulin secretion, gastric emptying, neurotransmission and epithelial repair.
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Hypothalamo-pituitary and immune-dependent adrenal regulation during systemic inflammation
Waldemar Kanczkowski,Vasileia Ismini Alexaki,Nguyen Tran,Sylvia Großklaus,Kai Zacharowski,Antoine Martinez,Petra Popovics,Petra Popovics,Petra Popovics,Norman L. Block,Norman L. Block,Triantafyllos Chavakis,Andrew V. Schally,Andrew V. Schally,Stefan R. Bornstein +14 more
TL;DR: The results suggest that immune cells, rather than adrenal cells, are major regulators of the systemic and intra-adrenal inflammatory response to LPS, and an important role of immune cellrather than adrenocortical MyD88 for adrenal inflammation and HPA-axis activation mediated by LPS.
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Synthesis of new potent agonistic analogs of growth hormone-releasing hormone (GHRH) and evaluation of their endocrine and cardiac activities.
Renzhi Cai,Andrew V. Schally,Tengjiao Cui,Luca Szalontay,Gabor Halmos,Wei Sha,Magdolna Kovacs,Miklós Jászberényi,Jinlin He,Ferenc G. Rick,Petra Popovics,Rosemeire M. Kanashiro-Takeuchi,Joshua M. Hare,Norman L. Block,Marta Zarandi +14 more
TL;DR: Three series of new analogs of GHRH(1-29) have been synthesized and evaluated biologically in an endeavor to produce more potent compounds and appear to be the most potent G HRH agonistic analogs so far developed.
Journal ArticleDOI
Synthesis and structure-activity studies on novel analogs of human growth hormone releasing hormone (GHRH) with enhanced inhibitory activities on tumor growth.
Marta Zarandi,Renzhi Cai,Magdolna Kovacs,Petra Popovics,Luca Szalontay,Tengjiao Cui,Wei Sha,Miklós Jászberényi,Jozsef L. Varga,Xian Yang Zhang,Norman L. Block,Ferenc G. Rick,Gabor Halmos,Andrew V. Schally +13 more
TL;DR: GHRH analogs of the Miami series powerfully suppress tumor growth, but have only a weak endocrine GH inhibitory activity, which could be induced by the downregulation of GHRH receptors levels.
Journal ArticleDOI
Beneficial effects of growth hormone-releasing hormone agonists on rat INS-1 cells and on streptozotocin-induced NOD/SCID mice
Xianyang Zhang,Xianyang Zhang,Tengjiao Cui,Tengjiao Cui,Jinlin He,Haibo Wang,Haibo Wang,Renzhi Cai,Renzhi Cai,Petra Popovics,Irving Vidaurre,Wei Sha,Wei Sha,Janine Schmid,Barbara Ludwig,Norman L. Block,Stefan R. Bornstein,Andrew V. Schally +17 more
TL;DR: This study demonstrates greater stimulation by improved GHRH agonists, on proliferation, gene expressions, and the signaling pathways in pancreatic β cells, supporting the use of GHRh agonists in type-1 diabetes.