P
Philip Brennecke
Researcher at Stanford University
Publications - 5
Citations - 1456
Philip Brennecke is an academic researcher from Stanford University. The author has contributed to research in topics: Noise & Population. The author has an hindex of 5, co-authored 5 publications receiving 1235 citations. Previous affiliations of Philip Brennecke include Wellcome Trust Centre for Stem Cell Research & European Bioinformatics Institute.
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Journal ArticleDOI
Accounting for technical noise in single-cell RNA-seq experiments
Philip Brennecke,Simon Anders,Jong Kyoung Kim,Aleksandra A. Kolodziejczyk,Aleksandra A. Kolodziejczyk,Xiuwei Zhang,Valentina Proserpio,Bianka Baying,Vladimir Benes,Sarah A. Teichmann,Sarah A. Teichmann,John C. Marioni,Marcus G. Heisler,Marcus G. Heisler +13 more
TL;DR: A quantitative statistical method is developed to distinguish true biological variability from the high levels of technical noise in single-cell experiments and quantifies the statistical significance of observed cell-to-cell variability in expression strength on a gene-by-gene basis.
Journal ArticleDOI
NuRD Suppresses Pluripotency Gene Expression to Promote Transcriptional Heterogeneity and Lineage Commitment
Nicola Reynolds,Paulina A. Latos,Antony Hynes-Allen,Antony Hynes-Allen,Remco Loos,Donna Leaford,Donna Leaford,Aoife O'Shaughnessy,Aoife O'Shaughnessy,Olukunbi Mosaku,Olukunbi Mosaku,Jason Signolet,Jason Signolet,Philip Brennecke,Tuezer Kalkan,Tuezer Kalkan,Ita Costello,Peter Humphreys,Peter Humphreys,William Mansfield,William Mansfield,Kentaro Nakagawa,John Strouboulis,Axel Behrens,Paul Bertone,Paul Bertone,Brian Hendrich,Brian Hendrich +27 more
TL;DR: The Nucleosome Remodeling and Deacetylation (NuRD) complex, which is required for ESC lineage commitment, modulates both transcriptional heterogeneity and the dynamic range of a set of pluripotency genes in ESCs.
Journal ArticleDOI
Myt1l safeguards neuronal identity by actively repressing many non-neuronal fates
Moritz Mall,Michael S. Kareta,Soham Chanda,Henrik Ahlenius,Nicholas Perotti,Bo Zhou,Sarah Grieder,Xuecai Ge,Sienna Drake,Cheen Euong Ang,Brandon M. Walker,Thomas Vierbuchen,Daniel R. Fuentes,Philip Brennecke,Kazuhiro R. Nitta,Arttu Jolma,Lars M. Steinmetz,Jussi Taipale,Jussi Taipale,Thomas C. Südhof,Marius Wernig +20 more
TL;DR: By studying the reprogramming of mouse fibroblasts to neurons, it is found that the pan neuron-specific transcription factor Myt1-like (Myt1l) exerts its pro-neuronal function by direct repression of many different somatic lineage programs except the neuronal program.
Journal ArticleDOI
Single-cell transcriptome analysis reveals coordinated ectopic gene-expression patterns in medullary thymic epithelial cells
Philip Brennecke,Alejandro Reyes,Sheena Pinto,Kristin Rattay,Michelle Nguyen,Rita Küchler,Wolfgang Huber,Bruno Kyewski,Lars M. Steinmetz +8 more
TL;DR: These findings characterize TRA expression in mTECs as a coordinated process that might involve local remodeling of chromatin and thus ensures a comprehensive representation of the immunological self.
Journal ArticleDOI
Corrigendum: Accounting for technical noise in single-cell RNA-seq experiments
Philip Brennecke,Simon Anders,Jong Kyoung Kim,Aleksandra A. Kolodziejczyk,Xiuwei Zhang,Valentina Proserpio,Bianka Baying,Vladimir Benes,Sarah A. Teichmann,John C. Marioni,Marcus G. Heisler +10 more
TL;DR: The dilution for the ERCC Spike-In Control Mix added to the lysis mix was given as 1:40,000 in the Online Methods and the actual dilution used was 1:400.