R
Remco Loos
Researcher at European Bioinformatics Institute
Publications - 39
Citations - 2974
Remco Loos is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: Embryonic stem cell & Time complexity. The author has an hindex of 13, co-authored 33 publications receiving 2526 citations. Previous affiliations of Remco Loos include Celgene & Rovira i Virgili University.
Papers
More filters
Journal ArticleDOI
Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human
Yasuhiro Takashima,Ge Guo,Remco Loos,Jennifer Nichols,Gabriella Ficz,Felix Krueger,David Oxley,Fátima Santos,James Clarke,William Mansfield,Wolf Reik,Paul Bertone,Paul Bertone,Austin Smith +13 more
TL;DR: It is reported that short-term expression of two components, NANOG and KLF2, is sufficient to ignite other elements of the network and reset the human pluripotent state and demonstrate feasibility of installing and propagating functional control circuitry for ground-state pluripotency in human cells.
Journal ArticleDOI
The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification
TL;DR: It is suggested that formation of the epiblast coincides with competence for ERK-independent self-renewal in vitro and consequent propagation as ESC lines and that ICM cells from early blastocysts can progress to ERK independence if provided with a specific laminin substrate.
Journal ArticleDOI
Lineage-Specific Profiling Delineates the Emergence and Progression of Naive Pluripotency in Mammalian Embryogenesis
Thorsten Boroviak,Remco Loos,Patrick Lombard,Junko Okahara,Rüdiger Behr,Erika Sasaki,Jennifer Nichols,Austin Smith,Paul Bertone,Paul Bertone +9 more
TL;DR: These findings support a conserved transcription factor foundation for naive pluripotency while revealing species-specific regulatory features of lineage segregation in rodents.
Journal ArticleDOI
Citrullination regulates pluripotency and histone H1 binding to chromatin
Maria A. Christophorou,Gonçalo Castelo-Branco,Richard P. Halley-Stott,Clara Slade Oliveira,Remco Loos,Aliaksandra Radzisheuskaya,Kerri A. Mowen,Paul Bertone,José C. R. Silva,Magdalena Zernicka-Goetz,Michael L. Nielsen,John B. Gurdon,Tony Kouzarides +12 more
TL;DR: A role for citrullination is uncovered in the regulation of pluripotency and new mechanistic insights are provided into how citruLLination regulates chromatin compaction.
Journal ArticleDOI
Transcriptional diversity during lineage commitment of human blood progenitors
Lu Chen,Lu Chen,Lu Chen,Myrto Kostadima,Myrto Kostadima,Myrto Kostadima,Joost H.A. Martens,Giovanni Canu,Giovanni Canu,Sara P. Garcia,Sara P. Garcia,Ernest Turro,Ernest Turro,Kate Downes,Kate Downes,Iain C. Macaulay,Ewa Bielczyk-Maczyńska,Ewa Bielczyk-Maczyńska,Sophia Coe,Sophia Coe,Samantha Farrow,Samantha Farrow,Pawan Poudel,Pawan Poudel,Frances Burden,Frances Burden,Sjoert B. G. Jansen,Sjoert B. G. Jansen,William J. Astle,William J. Astle,Antony P. Attwood,Antony P. Attwood,Tadbir K. Bariana,Bernard de Bono,Bernard de Bono,Alessandra Breschi,John C. Chambers,John C. Chambers,Fizzah A. Choudry,Fizzah A. Choudry,Laura Clarke,Paul Coupland,Martijn van der Ent,Wendy N. Erber,Joop H. Jansen,Rémi Favier,Matthew Fenech,Nicola Foad,Nicola Foad,Kathleen Freson,Chris Van Geet,Keith Gomez,Roderic Guigó,Daniel Hampshire,Daniel Hampshire,Anne M. Kelly,Anne M. Kelly,Anne M. Kelly,Hindrik H. D. Kerstens,Jaspal S. Kooner,Jaspal S. Kooner,Michael Laffan,Claire Lentaigne,Charlotte Labalette,Charlotte Labalette,Tiphaine Martin,Tiphaine Martin,Tiphaine Martin,Stuart Meacham,Stuart Meacham,Andrew D Mumford,Sylvia T. Nurnberg,Sylvia T. Nurnberg,Emilio Palumbo,Bert A. van der Reijden,David J. Richardson,Stephen John Sammut,Greg Slodkowicz,Asif U. Tamuri,Louella Vasquez,Katrin Voss,Katrin Voss,Stephen Watt,Sarah K Westbury,Paul Flicek,Paul Flicek,Remco Loos,Nick Goldman,Paul Bertone,Paul Bertone,Randy J. Read,Sylvia Richardson,Ana Cvejic,Ana Cvejic,Nicole Soranzo,Nicole Soranzo,Willem H. Ouwehand,Willem H. Ouwehand,Willem H. Ouwehand,Hendrik G. Stunnenberg,Mattia Frontini,Mattia Frontini,Augusto Rendon,Augusto Rendon +103 more
TL;DR: A previously undetected layer of regulation affecting cell fating is unveiled, which involves transcriptional isoforms switching without noticeable changes at the gene level and resulting in the gain or loss of protein functions in blood cells involved in the immune system.