P
Philip Hall
Researcher at Newcastle University
Publications - 2
Citations - 475
Philip Hall is an academic researcher from Newcastle University. The author has contributed to research in topics: mTORC2 & Non-homologous end joining. The author has an hindex of 2, co-authored 2 publications receiving 435 citations.
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Journal ArticleDOI
A systems study reveals concurrent activation of AMPK and mTOR by amino acids
Piero Dalle Pezze,Stefanie Ruf,Stefanie Ruf,Annika G Sonntag,Miriam Langelaar-Makkinje,Philip Hall,Alexander Martin Heberle,Patricia Razquin Navas,Patricia Razquin Navas,Karen van Eunen,Regine C Tölle,Jennifer J. Schwarz,Heike Wiese,Bettina Warscheid,Jana Deitersen,Björn Stork,Erik Fäßler,Sascha Schäuble,Udo Hahn,Peter Horvatovich,Daryl P. Shanley,Kathrin Thedieck,Kathrin Thedieck +22 more
TL;DR: It is found that aa acutely activate AMPK concurrently with mTOR, and it is shown that AMPK under aa sufficiency acts to sustain autophagy, which may be required to maintain protein homoeostasis and deliver metabolite intermediates for biosynthetic processes.
Journal ArticleDOI
Integrated Stochastic Model of DNA Damage Repair by Non-homologous End Joining and p53/p21- Mediated Early Senescence Signalling
David W. P. Dolan,Anze Zupanic,Glyn Nelson,Philip Hall,Satomi Miwa,Thomas B. L. Kirkwood,Daryl P. Shanley +6 more
TL;DR: This study has created an integrated stochastic model of DNA damage repair by non-homologous end joining and of gamma irradiation-induced cellular senescence in human cells that are not apoptosis-prone and predicts that low-dose fractionated irradiation of cells leads to temporal patterns in p53/p21 that lead to significant cellularsenescence.