J
Jana Deitersen
Researcher at University of Düsseldorf
Publications - 13
Citations - 710
Jana Deitersen is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: Autophagy & RIPK1. The author has an hindex of 7, co-authored 13 publications receiving 501 citations.
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Journal ArticleDOI
A systems study reveals concurrent activation of AMPK and mTOR by amino acids
Piero Dalle Pezze,Stefanie Ruf,Stefanie Ruf,Annika G Sonntag,Miriam Langelaar-Makkinje,Philip Hall,Alexander Martin Heberle,Patricia Razquin Navas,Patricia Razquin Navas,Karen van Eunen,Regine C Tölle,Jennifer J. Schwarz,Heike Wiese,Bettina Warscheid,Jana Deitersen,Björn Stork,Erik Fäßler,Sascha Schäuble,Udo Hahn,Peter Horvatovich,Daryl P. Shanley,Kathrin Thedieck,Kathrin Thedieck +22 more
TL;DR: It is found that aa acutely activate AMPK concurrently with mTOR, and it is shown that AMPK under aa sufficiency acts to sustain autophagy, which may be required to maintain protein homoeostasis and deliver metabolite intermediates for biosynthetic processes.
Journal ArticleDOI
Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells.
Yadong Sun,Niklas Berleth,Wenxian Wu,David Schlütermann,Jana Deitersen,Fabian Stuhldreier,Lena Berning,Annabelle Friedrich,Seda Akgün,María José Mendiburo,Sebastian Wesselborg,Marcus Conrad,Carsten Berndt,Björn Stork +13 more
TL;DR: In this paper, the authors found that Fin56 induces ferroptosis and autophagy in bladder cancer cells and that fin56-triggered FerroPTosis mechanistically depends on the autophagic machinery.
Journal ArticleDOI
Systematic analysis of ATG13 domain requirements for autophagy induction.
Nora Wallot-Hieke,Neha Verma,David Schlütermann,Niklas Berleth,Jana Deitersen,Philip Böhler,Fabian Stuhldreier,Wenxian Wu,Sabine Seggewiß,Christoph Peter,Holger Gohlke,Noboru Mizushima,Björn Stork +12 more
TL;DR: Targeting the ATG101-ATG13 interaction showed the strongest autophagy-inhibitory effect, whereas the inhibition of binding to ULK1 or RB1CC1 had only minor effects, emphasizing that mutations interfering with ULK 1 complex assembly do not necessarily result in a blockade of autophaky.
Journal ArticleDOI
The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death.
Wenxian Wu,Xiaojing Wang,Niklas Berleth,Jana Deitersen,Nora Wallot-Hieke,Philip Böhler,David Schlütermann,Fabian Stuhldreier,Jan Cox,Katharina Schmitz,Sabine Seggewiß,Christoph Peter,Gary Kasof,Anja Stefanski,Kai Stühler,Astrid Tschapek,Axel Gödecke,Björn Stork +17 more
TL;DR: It is proposed that ULK1 is a regulator of RIPK1-mediated cell death, and it appears that especially phosphorylation of S357 within the intermediate domain ofRIPK1 mediates this cell-death-inhibiting effect.
Journal ArticleDOI
Targeting urothelial carcinoma cells by combining cisplatin with a specific inhibitor of the autophagy-inducing class III PtdIns3K complex.
David Schlütermann,Margaretha A. Skowron,Niklas Berleth,Philip Böhler,Jana Deitersen,Fabian Stuhldreier,Nora Wallot-Hieke,Wenxian Wu,Christoph Peter,Michèle J. Hoffmann,Günter Niegisch,Björn Stork +11 more
TL;DR: It is proposed that targeting the autophagic machinery might represent a suitable approach to complement or even increase cisplatin efficacy in order to overcome cisPlatin resistance in urothelial carcinoma.