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Philip L. Lorenzi
Researcher at University of Texas MD Anderson Cancer Center
Publications - 128
Citations - 22127
Philip L. Lorenzi is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 37, co-authored 96 publications receiving 17665 citations. Previous affiliations of Philip L. Lorenzi include University of Michigan & Loyola University Chicago.
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Journal ArticleDOI
Fecal microbiome, metabolites, and stem cell transplant outcomes: A single-center pilot study
Jessica Galloway-Peña,Christine B. Peterson,Farida Malik,Pranoti Sahasrabhojane,Dimpy P. Shah,Chelcy E Brumlow,Lily G. Carlin,Roy F. Chemaly,Jin Seon Im,Gabriela Rondon,Edd Felix,Lucas Veillon,Philip L. Lorenzi,Amin M. Alousi,Robert R. Jenq,Dimitrios P. Kontoyiannis,Elizabeth J. Shpall,Samuel A. Shelburne,Pablo C. Okhuysen +18 more
TL;DR: Longitudinal analysis of fecal microbiome and metabolites after HSCT identified butyrate and indole as potential surrogate markers for microbial diversity and specific taxa.
Journal ArticleDOI
Mechanism of Catalysis by l-Asparaginase.
Jacek Lubkowski,Juan M. Vanegas,Wai Kin Chan,Philip L. Lorenzi,John N. Weinstein,Sergei Sukharev,David Fushman,Susan B. Rempe,Andriy Anishkin,Alexander Wlodawer +9 more
TL;DR: A detailed description of the reaction catalyzed by E. coli type II L-asparaginase (EcAII) is provided, providing strong evidence that EcAII catalyzes the reaction according to the double-displacement (ping-pong) mechanism, with formation of a covalent intermediate.
Journal ArticleDOI
A curated census of autophagy-modulating proteins and small molecules: candidate targets for cancer therapy.
TL;DR: A comprehensive, curated inventory of autophagy modulators is compiled by integrating information from published siRNA screens, multiple pathway analysis algorithms, and extensive, manually curated text-mining of the literature.
Journal ArticleDOI
Multiplexing siRNAs to compress RNAi-based screen size in human cells.
Scott E. Martin,Tamara L. Jones,Cheryl L. Thomas,Philip L. Lorenzi,Dac A. Nguyen,Timothy Runfola,Michele Gunsior,John N. Weinstein,Paul K. Goldsmith,Eric Lader,Konrad Huppi,Natasha J. Caplen +11 more
TL;DR: This study suggests that the screening of randomly multiplexed siRNAs may provide an important avenue towards the identification of candidate gene targets for downstream functional analyses and may also be useful for the rapid identification of positive controls for use in novel assay systems.
Journal ArticleDOI
Catalytic Role of the Substrate Defines Specificity of Therapeutic l-Asparaginase.
Andriy Anishkin,Juan M. Vanegas,David M. Rogers,Philip L. Lorenzi,Wai Kin Chan,Preeti Purwaha,John N. Weinstein,Sergei Sukharev,Susan B. Rempe +8 more
TL;DR: Evidence is presented that the aspartate product in the crystal structure of L-ASP exists in an unusual α-COOH protonation state, and a new hypothesis that the substrate's α-carboxyl serves as a proton acceptor and activates one of the catalytic threonines during L-asparaginases' nucleophilic attack on the amide carbon is explained.