Philipp Kolb

TL;DR: The evidence-based guidelines of the American Society of Hematology (ASH) are intended to support patients, clinicians, and other health care professionals in decisions about the use of anticoagulation for thromboprophylaxis for patients with COVID-19-related critical illness and acute illness who do not have confirmed or suspected venous thromboembolism (VTE) as mentioned in this paper.

TL;DR: It is suggested that 4-PBA may help fold proteins in the ER, attenuating the activation of the UPR, and thus potentially alleviating various pathologies, while also commenting on the possible mechanisms of action.

TL;DR: The data presented indicate that the UPR is activated in fibrotic lung tissue and strongly localized to macrophages and provides evidence that macrophage polarization and apoptosis may play a role in this process.

TL;DR: Despite an mPAP of <25 mm Hg, subjects with CTED show objective functional impairment and similar limitations to patients with CTEPH.

TL;DR: The bleomycin model is the standard model for pulmonary fibrosis, but it is often used incorrectly, as shown by this meta-analysis, and further characterisation of early inflammation and appropriate preclinical therapeutic testing are still needed.