P
Philippe Delerive
Researcher at Lille University of Science and Technology
Publications - 10
Citations - 3026
Philippe Delerive is an academic researcher from Lille University of Science and Technology. The author has contributed to research in topics: Receptor & Peroxisome proliferator-activated receptor. The author has an hindex of 10, co-authored 10 publications receiving 2906 citations. Previous affiliations of Philippe Delerive include Eli Lilly and Company.
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Journal ArticleDOI
Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1
Philippe Delerive,Karolien De Bosscher,Sandrine Besnard,Wim Vanden Berghe,Jeffrey M. Peters,Frank J. Gonzalez,Jean Charles Fruchart,Alain Tedgui,Guy Haegeman,Bart Staels +9 more
TL;DR: Fibrates inhibit the vascular inflammatory response via PPARα by interfering with the NF-κB and AP-1 transactivation capacity involving direct protein-protein interaction with p65 and c-Jun.
Journal ArticleDOI
Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages.
Giulia Chinetti,S. Griglio,M. Antonucci,Inés Pineda Torra,Philippe Delerive,Zouher Majd,Jean-Charles Fruchart,John Chapman,Jamila Najib,Bart Staels +9 more
TL;DR: It is shown that the PPARα and PPARγ forms are expressed in differentiated human monocyte-derived macrophages, which participate in inflammation control and atherosclerotic plaque formation and demonstrate a novel function of PPAR in human macrophage with likely consequences in inflammation and Atherosclerosis.
Journal ArticleDOI
Induction of IκBα Expression as a Mechanism Contributing to the Anti-inflammatory Activities of Peroxisome Proliferator-activated Receptor-α Activators
TL;DR: Fibrates, synthetic PPARα activators, induced the expression of the inhibitory protein IκBα in human aortic smooth muscle cells as well as in primary human hepatocytes, whereas neither IκK-kinase activity nor the degradation rate of Iκbα were affected.
Journal ArticleDOI
The orphan nuclear receptor RORα is a negative regulator of the inflammatory response
Philippe Delerive,Didier Monté,Guillaume Dubois,François Trottein,Jamila Fruchart-Najib,Jean Mariani,Jean-Charles Fruchart,Bart Staels +7 more
TL;DR: It is demonstrated that RORα is expressed in human primary smooth‐muscle cells and that ectopic expression of ROR α1 inhibits TNFα‐induced IL‐6, IL‐8 and COX‐2 expression in these cells, and this action is associated with the induction of IκBα, the major inhibitory protein of the NF‐κB signalling pathway.
Journal ArticleDOI
PGC-1 functions as a transcriptional coactivator for the retinoid X receptors.
TL;DR: Results indicate that PGC-1 is a bona fide coactivator for RXRα, and shows that P GC-1 and TIF2 synergistically enhance ligand-activated RXR α transcriptional activity.