P
Philippe Kastner
Researcher at University of Strasbourg
Publications - 118
Citations - 25684
Philippe Kastner is an academic researcher from University of Strasbourg. The author has contributed to research in topics: Retinoic acid & Retinoid X receptor. The author has an hindex of 64, co-authored 117 publications receiving 24827 citations. Previous affiliations of Philippe Kastner include University of Michigan & French Institute of Health and Medical Research.
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Journal ArticleDOI
The nuclear receptor superfamily: the second decade.
David J. Mangelsdorf,Carl S. Thummel,Miguel Beato,Peter Herrlich,Günther Schütz,Kazuhiko Umesono,Bruce Blumberg,Philippe Kastner,Manuel Mark,Pierre Chambon,Ronald M. Evans +10 more
TL;DR: This research presents a new probabilistic procedure called ‘spot-spot analysis’ to characterize the response of the immune system to the presence of E.coli.
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Two distinct estrogen‐regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B.
Philippe Kastner,Andrée Krust,Bernard Turcotte,U. Stropp,Laszlo Tora,Hinrich Gronemeyer,Pierre Chambon +6 more
TL;DR: Using the hPR gene 5′‐flanking sequences as promoter region in chimeric genes, it is shown that a functional promoter directs initiation of hPR mRNAs from the authentic start sites located at +1 and +15.
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Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently
Mark Leid,Mark Leid,Philippe Kastner,Philippe Kastner,Ruth Lyons,Ruth Lyons,Harikrishna Nakshatri,Harikrishna Nakshatri,Michael Saunders,Michael Saunders,Tim Zacharewski,Tim Zacharewski,Jia Yang Chen,Jia Yang Chen,Adrien Staub,Adrien Staub,Jean Marie Garnier,Jean Marie Garnier,Sylvie Mader,Sylvie Mader,Pierre Chambon,Pierre Chambon +21 more
TL;DR: It is shown that unstable RAR-RXR heterodimers were formed in solution, and that C-terminal sequences and the DNA-binding domains of both receptors were required for efficient formation of stable heterodIMers on response elements.
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Nonsteroid nuclear receptors: What Are genetic studies telling us about their role in real life?
TL;DR: Together with some nuclear receptor mutations associated with pathological conditions, knockouts have led to significant advances in the authors' knowledge of the physiological functions of several nuclear receptors, but have also raised unexpected problems.
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Multiplicity generates diversity in the retinoic acid signalling pathways
TL;DR: A complex array of combinatorial effects is beginning to emerge which may account for the pleiotropic effects of retinoids.