P
Philippe Veron
Researcher at French Institute of Health and Medical Research
Publications - 16
Citations - 3300
Philippe Veron is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Genetic enhancement & Biology. The author has an hindex of 9, co-authored 12 publications receiving 2882 citations. Previous affiliations of Philippe Veron include Université Paris-Saclay & Curie Institute.
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Journal ArticleDOI
Proteomic Analysis of Dendritic Cell-Derived Exosomes: A Secreted Subcellular Compartment Distinct from Apoptotic Vesicles
Clotilde Théry,Muriel Boussac,Philippe Veron,Paola Ricciardi-Castagnoli,Graça Raposo,Jérôme Garin,Sebastian Amigorena +6 more
TL;DR: Using a systematic proteomic approach, the first extensive protein map of a particular exosome population is established and a novel category of exosomal proteins related to apoptosis is identified: thioredoxin peroxidase II, Alix, 14-3-3, and galectin-3.
Journal ArticleDOI
Indirect activation of naïve CD4 + T cells by dendritic cell–derived exosomes
TL;DR: It is found that injection of antigen- or peptide-bearing exosomes induced antigen-specific naïve CD4+ T cell activation in vivo and may increase the number of DCs bearing a particular peptide, thus amplifying the initiation of primary adaptive immune responses.
Journal ArticleDOI
ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming
Elodie Segura,Carole Nicco,Carole Nicco,Bérangère Lombard,Bérangère Lombard,Philippe Veron,Philippe Veron,Graça Raposo,Graça Raposo,Frédéric Batteux,Frédéric Batteux,Sebastian Amigorena,Sebastian Amigorena,Clotilde Théry,Clotilde Théry +14 more
TL;DR: It is shown that exosomes secreted by lipopolysaccharide (LPS)-treated mature DCs are 50- to 100-fold more potent to induce antigen-specific T-cell activation in vitro than exosome from immature DCs.
Journal ArticleDOI
A critical role for Syk protein tyrosine kinase in Fc receptor-mediated antigen presentation and induction of dendritic cell maturation.
Christine Sedlik,Daniel Orbach,Philippe Veron,Edina Schweighoffer,Francesco Colucci,Romina Gamberale,Andrea Ioan-Facsinay,Sjef Verbeek,Paola Ricciardi-Castagnoli,Christian Bonnerot,Victor L. J. Tybulewicz,James P. Di Santo,Sebastian Amigorena +12 more
TL;DR: It is found that FcR engagement by immune complexes induced the phosphorylation of Syk, a protein tyrosine kinase acting immediately downstream of FcRs, which represents a novel pathway for the induction of DC maturation.
Journal ArticleDOI
Accumulation of MFG-E8/lactadherin on exosomes from immature dendritic cells.
TL;DR: This work shows that MFG-E8 is expressed by immature bone-marrow-derived DCs (BMDCs) and secreted in association with exosomes in vitro, and concludes that M FG-E 8 is efficiently targeted to exosome targeting but is not essential to address exosom targeting to mouse BMDCs.