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Phillip D. Fletcher
Researcher at UCL Institute of Neurology
Publications - 24
Citations - 898
Phillip D. Fletcher is an academic researcher from UCL Institute of Neurology. The author has contributed to research in topics: Semantic dementia & Frontotemporal dementia. The author has an hindex of 14, co-authored 24 publications receiving 732 citations. Previous affiliations of Phillip D. Fletcher include University College London.
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Journal ArticleDOI
The paradox of syndromic diversity in Alzheimer disease
TL;DR: It is argued that these apparently diverse clinical phenotypes of AD variant syndromes reflect the differential involvement of a common core temporoparietofrontal network that is vulnerable to AD.
Journal ArticleDOI
Primary progressive aphasia: a clinical approach.
Charles R. Marshall,Chris J.D. Hardy,Anna Volkmer,Lucy L. Russell,Rebecca L. Bond,Phillip D. Fletcher,Camilla N. Clark,Catherine J. Mummery,Jonathan M. Schott,Martin N. Rossor,Nick C. Fox,Sebastian J. Crutch,Jonathan D. Rohrer,Jason D. Warren +13 more
TL;DR: A clinical approach to the progressive aphasias is presented, based on the experience of these disorders and directed at non-specialists, and a prospect for future progress is concluded, emphasising generic information processing deficits and novel pathophysiological biomarkers.
Journal ArticleDOI
Pain and temperature processing in dementia: a clinical and neuroanatomical analysis
Phillip D. Fletcher,Laura E. Downey,Hannah L. Golden,Camilla N. Clark,Catherine F. Slattery,Ross W. Paterson,Jonathan D. Rohrer,Jonathan M. Schott,Martin N. Rossor,Jason D. Warren +9 more
TL;DR: Using a semi-structured caregiver questionnaire and MRI voxel-based morphometry in patients with frontotemporal degeneration or Alzheimer’s disease, Fletcher et al. show that symptoms are underpinned by atrophy in a distributed thalamo-temporo-insular network implicated in somatosensory processing.
Journal ArticleDOI
Longitudinal diffusion tensor imaging in frontotemporal dementia
Colin J. Mahoney,Ivor J. A. Simpson,Ivor J. A. Simpson,Jennifer M. Nicholas,Jennifer M. Nicholas,Phillip D. Fletcher,Laura E. Downey,Hannah L. Golden,Camilla N. Clark,Nicole Schmitz,Jonathan D. Rohrer,Jonathan M. Schott,Hui Zhang,Sebastian Ourselin,Sebastian Ourselin,Jason D. Warren,Nick C. Fox +16 more
TL;DR: In this article, trajectories of WM change using diffusion tensor imaging (DTI) were reported in a cohort with behavioral variant frontotemporal dementia (bvFTD), and sample size estimates using FA change were substantially lower than neuropsychological or whole brain measures of change.
Journal ArticleDOI
The brain basis of musicophilia: evidence from frontotemporal lobar degeneration.
TL;DR: A candidate brain substrate for musicophilia is suggested as a signature of distributed network damage that may reflect a shift of hedonic processing toward more abstract (non-social) stimuli, with some specificity for particular neurodegenerative pathologies.