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Catherine F. Slattery
Researcher at UCL Institute of Neurology
Publications - 40
Citations - 1117
Catherine F. Slattery is an academic researcher from UCL Institute of Neurology. The author has contributed to research in topics: Dementia & Posterior cortical atrophy. The author has an hindex of 16, co-authored 39 publications receiving 828 citations. Previous affiliations of Catherine F. Slattery include University College London & University of Cambridge.
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Journal ArticleDOI
R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia.
Catherine F. Slattery,Jon Beck,Lorna Harper,Gary Adamson,Zeinab Abdi,James Uphill,Tracy Campbell,Ron Druyeh,Colin J. Mahoney,Jonathan D. Rohrer,Janna Kenny,Jessica Lowe,Kelvin K. Leung,Josephine Barnes,Shona Clegg,Melanie Blair,Jennifer M. Nicholas,Rita Guerreiro,James B. Rowe,Claudia Ponto,Inga Zerr,Hans A. Kretzschmar,Pierluigi Gambetti,Sebastian J. Crutch,Jason D. Warren,Martin N. Rossor,Nick C. Fox,John Collinge,Jonathan M. Schott,Simon Mead +29 more
TL;DR: Rare TREM2 variants are significant risk factors for Alzheimer's disease (AD) and should be considered as a major risk factor for the disease.
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Pain and temperature processing in dementia: a clinical and neuroanatomical analysis
Phillip D. Fletcher,Laura E. Downey,Hannah L. Golden,Camilla N. Clark,Catherine F. Slattery,Ross W. Paterson,Jonathan D. Rohrer,Jonathan M. Schott,Martin N. Rossor,Jason D. Warren +9 more
TL;DR: Using a semi-structured caregiver questionnaire and MRI voxel-based morphometry in patients with frontotemporal degeneration or Alzheimer’s disease, Fletcher et al. show that symptoms are underpinned by atrophy in a distributed thalamo-temporo-insular network implicated in somatosensory processing.
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Cerebrospinal fluid in the differential diagnosis of Alzheimer’s disease: clinical utility of an extended panel of biomarkers in a specialist cognitive clinic
Ross W. Paterson,Catherine F. Slattery,Teresa Poole,Teresa Poole,Jennifer M. Nicholas,Jennifer M. Nicholas,Nadia K. Magdalinou,Jamie Toombs,Miles D. Chapman,Michael P. Lunn,Amanda Heslegrave,Martha S. Foiani,Philip S.J. Weston,Ashvini Keshavan,Jonathan D. Rohrer,Martin N. Rossor,Jason D. Warren,Catherine J. Mummery,Kaj Blennow,Nick C. Fox,Henrik Zetterberg,Jonathan M. Schott +21 more
TL;DR: CSF AβX-42/X-40 and T-tau/Aβ1–42 ratios have utility in distinguishing AD from controls, bvFTD, and SD, but none of the biomarkers tested had good specificity at distinguishingAD from DLB or PNFA.
Journal ArticleDOI
Cortical microstructure in young onset Alzheimer's disease using neurite orientation dispersion and density imaging.
Thomas D. Parker,Catherine F. Slattery,Jiaying Zhang,Jennifer M. Nicholas,Ross W. Paterson,Alexander J.M. Foulkes,Ian B. Malone,David L. Thomas,Marc Modat,David M. Cash,Sebastian J. Crutch,Daniel C. Alexander,Sebastien Ourselin,Nick C. Fox,Hui Zhang,Jonathan M. Schott +15 more
TL;DR: Data suggest distinct differences in cortical NDI and ODI occur in AD and these metrics provide pathologically relevant information beyond that of cortical thinning.
Journal ArticleDOI
ApoE influences regional white-matter axonal density loss in Alzheimer's disease
Catherine F. Slattery,Jiaying Zhang,Ross W. Paterson,Alexander J.M. Foulkes,Amelia M. Carton,Kirsty Macpherson,Laura Mancini,David L. Thomas,Marc Modat,Nicolas Toussaint,David M. Cash,John S. Thornton,Susie M.D. Henley,Sebastian J. Crutch,Daniel C. Alexander,Sebastien Ourselin,Nick C. Fox,Hui Zhang,Jonathan M. Schott +18 more
TL;DR: NODDI provides tissue-specific microstructural metrics ofwhite-matter tract damage in YOAD, including NDI which correlates with focal cognitive deficits, and APOEε4 status is associated with different patterns of white-matter neurodegeneration.