P
Pierre Luisi
Researcher at National University of Cordoba
Publications - 31
Citations - 1146
Pierre Luisi is an academic researcher from National University of Cordoba. The author has contributed to research in topics: Population & Natural selection. The author has an hindex of 15, co-authored 28 publications receiving 950 citations. Previous affiliations of Pierre Luisi include Institut national des sciences appliquées & Pompeu Fabra University.
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Journal ArticleDOI
The confounding effects of population structure, genetic diversity and the sampling scheme on the detection and quantification of population size changes.
Lounès Chikhi,Lounès Chikhi,Lounès Chikhi,Vitor C. Sousa,Vitor C. Sousa,Pierre Luisi,Pierre Luisi,Benoit Goossens,Benoit Goossens,Mark A. Beaumont +9 more
TL;DR: The results show that all three factors (genetic differentiation/gene flow, genetic diversity, and the sampling scheme) play a role in generating false bottleneck signals, and suggest an ad hoc method to counter this effect.
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1000 Genomes Selection Browser 1.0: a genome browser dedicated to signatures of natural selection in modern humans
Marc Pybus,Giovanni Marco Dall'Olio,Pierre Luisi,Manu Uzkudun,Angel Carreño-Torres,Pavlos Pavlidis,Hafid Laayouni,Jaume Bertranpetit,Johannes Engelken +8 more
TL;DR: The 1000 Genomes Selection Browser 1.0 is presented as a resource for signatures of recent natural selection in modern humans and will facilitate the interpretation of signals of selection on different temporal, geographical and genomic scales.
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Hierarchical boosting: a machine-learning framework to detect and classify hard selective sweeps in human populations.
Marc Pybus,Pierre Luisi,Giovanni Marco Dall'Olio,Manu Uzkudun,Hafid Laayouni,Jaume Bertranpetit,Johannes Engelken +6 more
TL;DR: This study improves detection of selective sweep by overcoming the classical selection versus no-selection classification strategy, and offers an explanation to the lack of consistency observed among selection tests when applied to real data.
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Human genomic regions with exceptionally high levels of population differentiation identified from 911 whole-genome sequences
Vincenza Colonna,Qasim Ayub,Yuan Chen,Luca Pagani,Pierre Luisi,Marc Pybus,Erik Garrison,Yali Xue,Chris Tyler-Smith,Gonçalo R. Abecasis,Adam Auton,Lisa D Brooks,Mark A DePristo,Richard Durbin,Robert E Handsaker,Hyun Min Kang,Gabor T. Marth,Gil McVean +17 more
TL;DR: It is demonstrated that while sites with low differentiation represent sampling effects rather than balancing selection, sites showing extremely high population differentiation are enriched for positive selection events and that one half may be the result of classic selective sweeps.
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Worldwide genetic variation at the 3′ untranslated region of the HLA-G gene: balancing selection influencing genetic diversity
Audrey Sabbagh,Pierre Luisi,Erick C. Castelli,Laure Gineau,Laure Gineau,D. Courtin,Jacqueline Milet,Juliana Doblas Massaro,Hafid Laayouni,Philippe Moreau,Eduardo Antônio Donadi,André Garcia,André Garcia +12 more
TL;DR: In this paper, the 3' untranslated region of the HLA-G gene was found to be a significant source of genetic variation at the global level, with balancing selection influencing genetic diversity.