L
Luca Pagani
Researcher at University of Padua
Publications - 137
Citations - 5330
Luca Pagani is an academic researcher from University of Padua. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 31, co-authored 111 publications receiving 4110 citations. Previous affiliations of Luca Pagani include University of Cambridge & University of Bologna.
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Journal ArticleDOI
The African Genome Variation Project shapes medical genetics in Africa
Deepti Gurdasani,Tommy Carstensen,Tommy Carstensen,Fasil Tekola-Ayele,Luca Pagani,Ioanna Tachmazidou,Konstantinos Hatzikotoulas,Savita Karthikeyan,Savita Karthikeyan,Louise Iles,Martin O. Pollard,Ananyo Choudhury,Graham R. S. Ritchie,Yali Xue,Jennifer L. Asimit,Rebecca N. Nsubuga,Elizabeth H. Young,Elizabeth H. Young,Cristina Pomilla,Cristina Pomilla,Katja Kivinen,K Rockett,Anatoli Kamali,Ayo P. Doumatey,Gershim Asiki,Janet Seeley,Fatoumatta Sisay-Joof,Muminatou Jallow,Stephen Tollman,Ephrem Mekonnen,Rosemary Ekong,Tamiru Oljira,Neil Bradman,Kalifa Bojang,Michèle Ramsay,Adebowale Adeyemo,Endashaw Bekele,Ayesha A. Motala,Shane A. Norris,Fraser J. Pirie,Pontiano Kaleebu,Dominic P. Kwiatkowski,Chris Tyler-Smith,Charles N. Rotimi,Eleftheria Zeggini,Manjinder S. Sandhu,Manjinder S. Sandhu +46 more
TL;DR: It is shown that modern imputation panels (sets of reference genotypes from which unobserved or missing genotypes in study sets can be inferred) can identify association signals at highly differentiated loci across populations in sub-Saharan Africa.
Journal ArticleDOI
Genomic analyses inform on migration events during the peopling of Eurasia
Luca Pagani,Luca Pagani,Luca Pagani,Daniel Lawson,Evelyn Jagoda,Evelyn Jagoda,Alexander Mörseburg,Anders Eriksson,Anders Eriksson,Mario Mitt,Florian Clemente,Florian Clemente,Georgi Hudjashov,Georgi Hudjashov,Georgi Hudjashov,Michael DeGiorgio,Lauri Saag,Jeffrey D. Wall,Alexia Cardona,Reedik Mägi,Melissa A. Wilson Sayres,Melissa A. Wilson Sayres,Sarah Kaewert,Charlotte E. Inchley,Christiana L. Scheib,Mari Järve,Monika Karmin,Monika Karmin,Monika Karmin,Guy S. Jacobs,Tiago Antao,Florin Mircea Iliescu,Alena Kushniarevich,Alena Kushniarevich,Qasim Ayub,Chris Tyler-Smith,Yali Xue,Bayazit Yunusbayev,Kristiina Tambets,Chandana Basu Mallick,Lehti Saag,Elvira Pocheshkhova,George Andriadze,Craig Muller,Michael C. Westaway,David M. Lambert,Grigor Zoraqi,Shahlo Turdikulova,Dilbar Dalimova,Zhaxylyk Sabitov,Gazi Nurun Nahar Sultana,Joseph Lachance,Joseph Lachance,Sarah A. Tishkoff,Kuvat T. Momynaliev,Jainagul Isakova,Larisa Damba,Marina Gubina,Pagbajabyn Nymadawa,Irina Evseeva,L. A. Atramentova,Olga Utevska,François-Xavier Ricaut,Nicolas Brucato,Herawati Sudoyo,Thierry Letellier,Murray P. Cox,Nikolay A. Barashkov,Vedrana Škaro,Lejla Mulahasanovic,Dragan Primorac,Hovhannes Sahakyan,Hovhannes Sahakyan,Maru Mormina,Christina A. Eichstaedt,Christina A. Eichstaedt,Daria V. Lichman,Daria V. Lichman,S M Abdullah,Gyaneshwer Chaubey,Joseph Wee,Evelin Mihailov,A. S. Karunas,Sergei Litvinov,Sergei Litvinov,Rita Khusainova,N. V. Ekomasova,V. L. Akhmetova,I. M. Khidiyatova,Damir Marjanović,Levon Yepiskoposyan,Doron M. Behar,Elena Balanovska,Andres Metspalu,Miroslava Derenko,Boris Malyarchuk,Mikhail Voevoda,Mikhail Voevoda,Mikhail Voevoda,Sardana A. Fedorova,Ludmila P. Osipova,Ludmila P. Osipova,Marta Mirazón Lahr,Pascale Gerbault,Matthew Leavesley,Matthew Leavesley,Andrea Bamberg Migliano,Michael D. Petraglia,Oleg Balanovsky,Elza Khusnutdinova,Ene Metspalu,Ene Metspalu,Mark G. Thomas,Andrea Manica,Rasmus Nielsen,Richard Villems,Richard Villems,Richard Villems,Eske Willerslev,Toomas Kivisild,Toomas Kivisild,Mait Metspalu +121 more
TL;DR: A genetic signature in present-day Papuans that suggests that at least 2% of their genome originates from an early and largely extinct expansion of anatomically modern humans (AMHs) out of Africa earlier than 75,000 years ago is found.
Journal ArticleDOI
A recent bottleneck of Y chromosome diversity coincides with a global change in culture
Monika Karmin,Monika Karmin,Lauri Saag,Lauri Saag,Mário Vicente,Melissa A. Wilson Sayres,Melissa A. Wilson Sayres,Mari Järve,Ulvi Gerst Talas,Siiri Rootsi,Anne-Mai Ilumäe,Anne-Mai Ilumäe,Reedik Mägi,Mario Mitt,Luca Pagani,Tarmo Puurand,Zuzana Faltyskova,Florian Clemente,Alexia Cardona,Ene Metspalu,Ene Metspalu,Hovhannes Sahakyan,Hovhannes Sahakyan,Bayazit Yunusbayev,Bayazit Yunusbayev,Georgi Hudjashov,Georgi Hudjashov,Michael DeGiorgio,Eva Liis Loogväli,Christina A. Eichstaedt,Mikk Eelmets,Mikk Eelmets,Gyaneshwer Chaubey,Kristiina Tambets,S. S. Litvinov,S. S. Litvinov,Maru Mormina,Yali Xue,Qasim Ayub,Grigor Zoraqi,Thorfinn Sand Korneliussen,Thorfinn Sand Korneliussen,Farida Akhatova,Farida Akhatova,Joseph Lachance,Joseph Lachance,Sarah A. Tishkoff,Kuvat T. Momynaliev,François-Xavier Ricaut,Pradiptajati Kusuma,Pradiptajati Kusuma,Harilanto Razafindrazaka,Denis Pierron,Murray P. Cox,Gazi Nurun Nahar Sultana,Rane Willerslev,Craig Muller,Michael C. Westaway,David M. Lambert,Vedrana Škaro,Lejla Kovacevic,Shahlo Turdikulova,Dilbar Dalimova,Rita Khusainova,Rita Khusainova,N. N. Trofimova,N. N. Trofimova,V. L. Akhmetova,I. M. Khidiyatova,I. M. Khidiyatova,Daria V. Lichman,Jainagul Isakova,Elvira Pocheshkhova,Zhaxylyk Sabitov,Zhaxylyk Sabitov,Nikolay A. Barashkov,Pagbajabyn Nymadawa,Evelin Mihailov,Joseph Wee Tien Seng,Irina Evseeva,Andrea Bamberg Migliano,S M Abdullah,George Andriadze,Dragan Primorac,L. A. Atramentova,Olga Utevska,Levon Yepiskoposyan,Damir Marjanović,Alena Kushniarevich,Alena Kushniarevich,Doron M. Behar,Christian Gilissen,Lisenka E.L.M. Vissers,Joris A. Veltman,Elena Balanovska,Miroslava Derenko,Boris Malyarchuk,Andres Metspalu,Sardana A. Fedorova,Anders Eriksson,Anders Eriksson,Andrea Manica,Fernando L. Mendez,Tatiana M. Karafet,Krishna R. Veeramah,Neil Bradman,Michael F. Hammer,Ludmila P. Osipova,Oleg Balanovsky,Elza Khusnutdinova,Elza Khusnutdinova,Knut Johnsen,Maido Remm,Mark G. Thomas,Chris Tyler-Smith,Peter A. Underhill,Eske Willerslev,Rasmus Nielsen,Mait Metspalu,Mait Metspalu,Richard Villems,Richard Villems,Richard Villems,Toomas Kivisild,Toomas Kivisild +124 more
TL;DR: A study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples, infer a second strong bottleneck in Y-chromosome lineages dating to the last 10 ky, and hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males.
Journal ArticleDOI
Mountain gorilla genomes reveal the impact of long-term population decline and inbreeding
Yali Xue,Javier Prado-Martinez,Peter H. Sudmant,Vagheesh M. Narasimhan,Vagheesh M. Narasimhan,Qasim Ayub,Michal Szpak,Peter Frandsen,Yuan Chen,Bryndis Yngvadottir,David Neil Cooper,Marc de Manuel,Jessica Hernandez-Rodriguez,Irene Lobon,Hans R. Siegismund,Luca Pagani,Luca Pagani,Michael A. Quail,Christina Hvilsom,Antoine Mudakikwa,Evan E. Eichler,Evan E. Eichler,Michael R. Cranfield,Tomas Marques-Bonet,Chris Tyler-Smith,Aylwyn Scally +25 more
TL;DR: It is found that the two eastern subspecies have experienced a prolonged population decline over the past 100,000 years, resulting in very low genetic diversity and an increased overall burden of deleterious variation.
Journal ArticleDOI
Correction: Corrigendum: Geographic population structure analysis of worldwide human populations infers their biogeographical origins
Eran Elhaik,Tatiana V. Tatarinova,Dmitri Chebotarev,Ignazio S. Piras,Carla Maria Calò,Antonella De Montis,Manuela Atzori,Monica Marini,Sergio Tofanelli,Paolo Francalacci,Luca Pagani,Chris Tyler-Smith,Yali Xue,Francesco Cucca,Theodore G. Schurr,Jill B. Gaieski,Carlalynne Melendez,Miguel G. Vilar,Amanda C. Owings,Rocío Gómez,Ricardo Fujita,Fabrício R. Santos,David Comas,Oleg Balanovsky,Elena Balanovska,Pierre Zalloua,Himla Soodyall,Ramasamy Pitchappan,ArunKumar GaneshPrasad,Michael F. Hammer,Lisa Matisoo-Smith,R. Spencer Wells +31 more
TL;DR: A revised declaration that lists potentially competing financial interests is provided below: A.M.M., M.D. and M.A.are affiliated with Bcs Biotech S.A., and the declaration is revised to reflect this.