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Pierre-Olivier Mari
Researcher at Claude Bernard University Lyon 1
Publications - 24
Citations - 1090
Pierre-Olivier Mari is an academic researcher from Claude Bernard University Lyon 1. The author has contributed to research in topics: DNA repair & Nucleotide excision repair. The author has an hindex of 13, co-authored 21 publications receiving 985 citations. Previous affiliations of Pierre-Olivier Mari include University of Toulouse & Paul Sabatier University.
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Journal ArticleDOI
Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4
Pierre-Olivier Mari,Bogdan I. Florea,Stephan P. Persengiev,Nicole S. Verkaik,Hennie T. Brüggenwirth,Mauro Modesti,Giuseppina Giglia-Mari,Karel Bezstarosti,Jeroen Demmers,Theo M. Luider,Adriaan B. Houtsmuller,Dik C. van Gent +11 more
TL;DR: Evidence is provided that a pulsed near IR laser can produce DSBs without any visible alterations in the nucleus, and it is shown that NHEJ proteins accumulate in the irradiated areas, and that XRCC4 may serve as a flexible tether between Ku70/80 and ligase IV.
Journal ArticleDOI
A ubiquitin-binding domain in Cockayne syndrome B required for transcription-coupled nucleotide excision repair.
Roy Anindya,Pierre-Olivier Mari,Ulrik Kristensen,Hanneke Kool,Giuseppina Giglia-Mari,Leon H.F. Mullenders,Maria Fousteri,Wim Vermeulen,Jean-Marc Egly,Jesper Q. Svejstrup +9 more
TL;DR: It is shown that CSB contains a ubiquitin-binding domain (UBD), indicating an essential role for protein ubiquitylation and CSB's UBD in triggering damage incision during TC-NER and allowing us to integrate the function of CSA andCSB in a model for the process.
Journal ArticleDOI
Dynamic Interaction of TTDA with TFIIH Is Stabilized by Nucleotide Excision Repair in Living Cells
Giuseppina Giglia-Mari,Catherine Miquel,Arjan F. Theil,Pierre-Olivier Mari,Deborah Hoogstraten,Jessica M. Y. Ng,Christoffel Dinant,Jan H.J. Hoeijmakers,Wim Vermeulen +8 more
TL;DR: Interestingly, DNA conformations that only provoke an abortive-type of NER reaction do not result into a more stable incorporation of TTDA into TFIIH, indicating that its interaction withTFIIH reflects productive NER.
Journal ArticleDOI
Histone Methyltransferase DOT1L Drives Recovery of Gene Expression after a Genotoxic Attack
Valentyn Oksenych,Alexander Zhovmer,Salim Ziani,Pierre-Olivier Mari,Jitka Eberova,Tiziana Nardo,Miria Stefanini,Giuseppina Giglia-Mari,Jean-Marc Egly,Frédéric Coin +9 more
TL;DR: It is suggested that DOT1L secures an open chromatin structure in order to reactivate RNA Pol II transcription initiation after a genotoxic attack and treatment with Trichostatin A, relaxing chromatin, recovers both transcription initiation and UV-survival.
Journal ArticleDOI
Differentiation driven changes in the dynamic organization of Basal transcription initiation.
Giuseppina Giglia-Mari,Giuseppina Giglia-Mari,Giuseppina Giglia-Mari,Arjan F. Theil,Pierre-Olivier Mari,Pierre-Olivier Mari,Pierre-Olivier Mari,Sophie Mourgues,Sophie Mourgues,Julie Nonnekens,Lise O. Andrieux,Jan de Wit,Catherine Miquel,Nils Wijgers,Alex Maas,Maria Fousteri,Jan H.J. Hoeijmakers,Wim Vermeulen +17 more
TL;DR: A novel mouse model reveals that the dynamic behavior of transcription factors can vary considerably between different cells of an organism.