P
Pierre Renard
Researcher at University of Caen Lower Normandy
Publications - 154
Citations - 4362
Pierre Renard is an academic researcher from University of Caen Lower Normandy. The author has contributed to research in topics: Melatonin & Receptor. The author has an hindex of 34, co-authored 154 publications receiving 4150 citations. Previous affiliations of Pierre Renard include Blaise Pascal University & Paul Sabatier University.
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Journal ArticleDOI
Agomelatine, the first melatonergic antidepressant: discovery, characterization and development.
Christian de Bodinat,Beatrice Guardiola-Lemaitre,Elisabeth Mocaer,Pierre Renard,Carmen Muńoz,Millan Mark +5 more
TL;DR: Agomelatine (Valdoxan/Thymanax; Servier) was granted marketing authorization in 2009 for the treatment of major depression in Europe, thereby becoming the first approved antidepressant to incorporate a non-monoaminergic mechanism of action.
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Melatonin Reduces Body Weight Gain in Sprague Dawley Rats with Diet-Induced Obesity
Bénédicte Prunet-Marcassus,Mathieu Desbazeille,Arnaud Bros,Katie Louche,Philippe Delagrange,Pierre Renard,Louis Casteilla,Luc Pénicaud +7 more
TL;DR: It is demonstrated that melatonin may act as a regulator of body weight in a model of obesity and may prevent some of the side effects on glucose homeostasis such as decreased insulin sensitivity.
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New selective ligands of human cloned melatonin MT1 and MT2 receptors.
Valérie Audinot,François Mailliet,Chantal Lahaye-Brasseur,Anne Bonnaud,Aude Le Gall,Christophe Amossé,Sandra Dromaint,Marianne Rodriguez,Nadine Nagel,Jean-Pierre Galizzi,Benoît Malpaux,Gérald Guillaumet,Daniel Lesieur,François Lefoulon,Pierre Renard,Philippe Delagrange,Jean A. Boutin +16 more
TL;DR: The most potent melatonin receptor agonist, S 25150, is discovered, so far reported in the literature, and new types of selective antagonists, such as S 25567 and S 26131 for MT1 and S 24601 for MT2 are reported.
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Melatonin analogues as agonists and antagonists in the circadian system and other brain areas
Shui-Wang Ying,Benjamin Rusak,Philippe Delagrange,Elisabeth Mocaer,Pierre Renard,Beatrice Guardiola-Lemaitre +5 more
TL;DR: Results indicate that S20098 is an agonist acting probably on melatonin receptors in the Syrian hamster brain, and S20928 may have mixed agonist/antagonist properties, but at low doses appears to function as an antagonist at melatonin receptor in the suprachiasmatic nucleus and intergeniculate leaflet.
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Structure-activity relationships and structural conformation of a novel urotensin II-related peptide.
David Chatenet,Christophe Dubessy,Jérôme Leprince,Cédric Boularan,Ludovic Carlier,Isabelle Ségalas-Milazzo,Laure Guilhaudis,Hassan Oulyadi,Daniel Davoust,Elizabeth Scalbert,Bruno Pfeiffer,Pierre Renard,Marie-Christine Tonon,Isabelle Lihrmann,Pierre Pacaud,Hubert Vaudry +15 more
TL;DR: This work synthesized a series of URP analogs and measured their binding affinity on hGPR14-transfected cells and their contractile activity in a rat aortic ring bioassay to find the most potent antagonist in this series.