P
Philippe Chavatte
Researcher at university of lille
Publications - 98
Citations - 2663
Philippe Chavatte is an academic researcher from university of lille. The author has contributed to research in topics: Receptor & G protein-coupled receptor. The author has an hindex of 23, co-authored 97 publications receiving 2432 citations. Previous affiliations of Philippe Chavatte include Lille University of Science and Technology.
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Journal ArticleDOI
Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma.
Christel Rousseaux,Bruno Lefebvre,Laurent Dubuquoy,Philippe Lefebvre,Olivier Romano,Johan Auwerx,Daniel Metzger,Walter Wahli,Béatrice Desvergne,Gian Carlo Naccari,Philippe Chavatte,Amaury Farce,Philippe Bulois,Antoine Cortot,Jean-Frederic Colombel,Pierre Desreumaux +15 more
TL;DR: PPAR-γ is identified as a target of 5-ASA underlying antiinflammatory effects in the colon, and its activities are associated with the recruitment of coactivators and the activation of a peroxisome-proliferator response element–driven gene.
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PPARγ as a new therapeutic target in inflammatory bowel diseases
Laurent Dubuquoy,Christel Rousseaux,Xavier Thuru,Laurent Peyrin-Biroulet,Olivier Romano,Philippe Chavatte,Mathias Chamaillard,Pierre Desreumaux +7 more
TL;DR: The peroxisome proliferator activated receptor γ (PPARγ) is a nuclear receptor highly expressed in the colon and playing a key role in bacterial induced inflammation Regulation of colon inflammation by this receptor has been well demonstrated in many experimental models of colitis but also in patients with ulcerative colitis, characterised by impaired expression of PPARγ confined to their colon epithelial cells as discussed by the authors.
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Targeting Peroxisome Proliferator-Activated Receptors (PPARs): Development of Modulators
Celine Pirat,Amaury Farce,Nicolas Lebegue,Nicolas Renault,Christophe Furman,Régis Millet,Saïd Yous,Silvia Speca,Pascal Berthelot,Pierre Desreumaux,Philippe Chavatte +10 more
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Three-dimensional quantitative structure-activity relationships of cyclo-oxygenase-2 (COX-2) inhibitors: a comparative molecular field analysis.
TL;DR: The high level of compatibility with the COX-2 enzyme topology shows the great accuracy of this model that can predict inhibitory activities for a wide range of compounds and offers important structural insight into designing novel antiinflammatory drugs prior to their synthesis.
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Therapeutic Potential of Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, and N-Acylethanolamine Acid Amidase Inhibitors.
Wei Tuo,Natascha Leleu-Chavain,John Spencer,Supojjanee Sansook,Régis Millet,Philippe Chavatte +5 more
TL;DR: Increasing the concentration of FAEs and ECs through the inhibition of degrading enzymes has been considered to be a viable therapeutic approach to enhance their antinociceptive and anti-inflammatory effects, as well as to protect the nervous system.