P
Pieter R. Cullis
Researcher at University of British Columbia
Publications - 472
Citations - 55317
Pieter R. Cullis is an academic researcher from University of British Columbia. The author has contributed to research in topics: Liposome & Vesicle. The author has an hindex of 113, co-authored 458 publications receiving 49522 citations. Previous affiliations of Pieter R. Cullis include Utrecht University & Princeton University.
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Drug Delivery Systems: Entering the Mainstream
TL;DR: There is considerable interest in exploiting the advantages of DDS for in vivo delivery of new drugs derived from proteomics or genomics research and for their use in ligand-targeted therapeutics.
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Liposomal drug delivery systems: from concept to clinical applications.
TL;DR: Lipidic nanoparticles are the first nanomedicine delivery system to make the transition from concept to clinical application, and they are now an established technology platform with considerable clinical acceptance.
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Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential
TL;DR: A technique for the rapid production of large unilamellar vesicles by repeated extrusion under moderate pressures by employing the lipophilic cation methyltriphenylphosphonium (MTPP⁺) and LUVET systems exhibiting a membrane potential in response to a transmembrane Na⁺/K⁺ gradient have been characterized.
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Lipid polymorphism and the functional roles of lipids in biological membranes.
Pieter R. Cullis,B. de Kruijff +1 more
TL;DR: The possible functional roles of lipids are reviewed in terms of previous models such as the fluid mosaic model of Singer and Nicolson or the earlier unit membrane model so that the requirement for an alternative approach becomes apparent.
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Vesicles of variable sizes produced by a rapid extrusion procedure
TL;DR: Freeze-fracture electron microscopy revealed that vesicles produced at very high lipid concentrations exhibit size distributions and extent of multilamellar character comparable to systems produced at lower lipid levels.