Lipid polymorphism and the functional roles of lipids in biological membranes.
Pieter R. Cullis,B. de Kruijff +1 more
TLDR
The possible functional roles of lipids are reviewed in terms of previous models such as the fluid mosaic model of Singer and Nicolson or the earlier unit membrane model so that the requirement for an alternative approach becomes apparent.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 1979-12-20 and is currently open access. It has received 1751 citations till now. The article focuses on the topics: Fluid mosaic model & Biological membrane.read more
Citations
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Molecular basis of bacterial outer membrane permeability.
Hiroshi Nikaido,Martti Vaara +1 more
TL;DR: It is becoming increasingly clear that the outer membrane is very important in the physiology of gram-negative bacteria in making them resistant to host defense factors such as lysozyme, P-lysin, and various leukocyte proteins.
Journal ArticleDOI
Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential
TL;DR: A technique for the rapid production of large unilamellar vesicles by repeated extrusion under moderate pressures by employing the lipophilic cation methyltriphenylphosphonium (MTPP⁺) and LUVET systems exhibiting a membrane potential in response to a transmembrane Na⁺/K⁺ gradient have been characterized.
Journal ArticleDOI
Physical principles of membrane organization.
TL;DR: An understanding of the physical principles that govern the molecular organization of membranes is essential for an understanding of their physiological roles since structure and function are much more interdependent in membranes than in, say, simple chemical reactions in solution.
Journal ArticleDOI
How lipids affect the activities of integral membrane proteins
TL;DR: The role of non-annular, or 'co-factor' lipids, tightly bound to membrane proteins, is described, as well as the effects of charged lipids on ion concentrations close to the surface of the bilayer.
Journal ArticleDOI
Structure of the inverted hexagonal (HII) phase, and non-lamellar phase transitions of lipids.
TL;DR: The chiral stationary phase transitions of non-lamellar phase transitions are studied to show the role of chiral reprograming in the evolution of phase-by-phase chiral phase transitions.
References
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Journal ArticleDOI
The fluid mosaic model of the structure of cell membranes.
S. J. Singer,Garth L. Nicolson +1 more
TL;DR: Results strongly indicate that the bivalent antibodies produce an aggregation of the surface immunoglobulin molecules in the plane of the membrane, which can occur only if the immunoglOBulin molecules are free to diffuse in the membrane.
Journal Article
The Membrane Actions of Anesthetics and Tranquilizers
TL;DR: A diagrammatic summary of the membrane actions of anesthetics and tran-quilizers is shown, and the membrane fluidization may explain the enhanced neurosecretion of membrane-bound materials, by a mechanism of membranes-membrane fusion.
Book
Lysosomes in biology and pathology
TL;DR: By reading this book as soon as possible, you can renew the situation to get the inspirations and will lead you to always think more and more.
Journal ArticleDOI
Theory of self-assembly of lipid bilayers and vesicles
TL;DR: A unified theory is developed that explains the formation of bilayers and vesicles and accounts quantitatively for many of their physical properties: properties including vesicle size distributions and bilayer elasticity emerge from a unified theory that links thermodynamics, interaction free energy, and molecular geometry.